Protein Info for SMc02836 in Sinorhizobium meliloti 1021

Annotation: ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 601 transmembrane" amino acids 35 to 56 (22 residues), see Phobius details amino acids 71 to 89 (19 residues), see Phobius details amino acids 146 to 167 (22 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 262 to 280 (19 residues), see Phobius details amino acids 287 to 306 (20 residues), see Phobius details PF00664: ABC_membrane" amino acids 37 to 299 (263 residues), 129.4 bits, see alignment E=2.1e-41 PF00005: ABC_tran" amino acids 368 to 517 (150 residues), 111.1 bits, see alignment E=6.7e-36

Best Hits

Swiss-Prot: 34% identical to MSBA_VIBPA: Lipid A export ATP-binding/permease protein MsbA (msbA) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 100% identity to sme:SMc02836)

MetaCyc: 58% identical to lipid A-core oligosaccharide flippase (Brucella abortus 2308)
RXN2B4Q-67 [EC: 7.5.2.6]

Predicted SEED Role

No annotation

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92T26 at UniProt or InterPro

Protein Sequence (601 amino acids)

>SMc02836 ABC transporter ATP-binding protein (Sinorhizobium meliloti 1021)
MNAKDRNKRAVDSETITGILKRVIAENGRDHIRGYAFAIACLVVVAATTGFTAWIMEAVV
NEAFANRRADIVLLICGAIFAAFVLRGLATYGQAVALSKIGNNIVARYQRRLYAHLMALS
VGYFHEHRSAQLAAKVSQNVSGIRDVLNMTVTSIARDLLTLIGLVVVMFSKDWLLSLIVF
FVAPPLLLGLRYISRRLRLATREAVEVNSRVLGAMQETIQGITIVKAFTMENELRRKVES
IIDRAENRANRIARLSERTAPMTETFAGLAISSVLAYAAFRTIYHNVPPGAFFAFVTALL
MAYDPARRLARLQVSMERAAVNARMIYEILDTVPHQRDRPDATELRLGEATVELRDVRFA
YGTGEEILKGVSFRAEGGKTTALVGPSGAGKSTIISLIPRFYDPLSGEILIDGQNIAGVT
KQSLRAGLAYVSQQPYLFEGSIRDNIRYGRPDATDAEIEEAARLAYAHDFILAQPQGYDT
PVGEHGVTLSGGQRQRLSIARALVRNAPVLLLDEATSALDTESEAAVQKALEEAMSGRTV
IVIAHRLSTVVNADKIVVMKEGIVVEEGSHEELARRPDGLYARLHNLQGSGADTVAEAQI
L