Protein Info for SMc02775 in Sinorhizobium meliloti 1021
Updated annotation (from data): D-arabinose 1-dehydrogenase
Rationale: Specifically important in carbon source D-Arabinose. This is the first step in the oxidation of D-arabinose. (The fucose dehydrogenase is SM_b21109.) The product is probably the 1,5-lactone, not the 1,4-lactone, see SM_b21101.
Original annotation: L-fucose dehydrogenase (D-threo aldose 1-dehydrogenase) protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00064, D-threo-aldose 1-dehydrogenase [EC: 1.1.1.122] (inferred from 100% identity to sme:SMc02775)Predicted SEED Role
"L-fuco-beta-pyranose dehydrogenase (EC 1.1.1.122)" (EC 1.1.1.122)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.122
Use Curated BLAST to search for 1.1.1.122
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92TD8 at UniProt or InterPro
Protein Sequence (339 amino acids)
>SMc02775 D-arabinose 1-dehydrogenase (Sinorhizobium meliloti 1021) MQTRRIGRTALAVTEYSFGTAGLGGLYRECTREAAMATLDAAWEAGIRYFDTAPFYGLGL AERRVGDFLRDKPRDSFVLSTKVGRLLHPVPENQVPDYSYVKPLNFDVTYDYGYDAIMRS VEMSYARLGLNRIDILYVHDIGGYTHGAAKNAVYLRQLLDSGLKALDELKSSGVISAYGL GVNEVPVCLDVMRQADIDCILLAGRYTLLDRSAVAELLPLCAKKDTSLVVGGVFNSGILA TGPVEGAHFDYMPATGEVRAKVAAMERIAGERGMPLAAPALQFPLANPHVASVLLGTAKP SSLTRNMELTRYGIAPEDYAAFEPHTLVAPELGPEAVRA