Protein Info for SMc02760 in Sinorhizobium meliloti 1021

Annotation: ATP-dependent nuclease/helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1189 PF00580: UvrD-helicase" amino acids 21 to 475 (455 residues), 164.9 bits, see alignment E=9.5e-52 TIGR02784: double-strand break repair helicase AddA" amino acids 22 to 1172 (1151 residues), 1617.4 bits, see alignment E=0 PF13245: AAA_19" amino acids 31 to 89 (59 residues), 29.2 bits, see alignment 2.8e-10 PF13361: UvrD_C" amino acids 771 to 897 (127 residues), 51.7 bits, see alignment E=2.8e-17 PF12705: PDDEXK_1" amino acids 1020 to 1169 (150 residues), 41.3 bits, see alignment E=5.7e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMc02760)

Predicted SEED Role

"FIG061771: ATP-dependent nuclease subunit A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92TC4 at UniProt or InterPro

Protein Sequence (1189 amino acids)

>SMc02760 ATP-dependent nuclease/helicase (Sinorhizobium meliloti 1021)
MRSDATGPEERSPEGWLDWTTQRQALASDPACSAWVSANAGSGKTHVLTQRVIRLLLAGC
RPSAILCLTYTKAAASEMSNRVFEKLAEWATLDDTTLEKRIEAIEGKRPPTAKIQEARRL
FARALETPGGLKIQTIHAFCEALLHQFPLEANVAGHFSVLDDRAAAVLLADARRALLTAT
AAASDGELAEAFATVLDLADDTGLEKLLAAIVANRAPIQAFLDHASGRGGMEAHLRAALG
LEPGETAGTVMAAVWPLAGLNGPALDDYIDLGLRLGGAKPSAIADGLRAVRAIDDAATRY
SKLVELFFNGGGKPKAESAFLNAAMRRAAPQLELRVEEARSHMLACVDRLSIVQMYGATR
AALVLAERLNRDYEALKKARSQLDFEDLIHRTAALLARSDVGAWVHYKLDQGIDHILVDE
AQDTSPAQWTIIQSLAADFFAGETARADDRTIFAVGDEKQSIYSFQGARPERFSRESTLT
ERRVRAGNKHFSPIRLQLSFRSTVDVLSAVDTVFANPGNARGLSARSEAIVHASNRIGQP
GAVDLWDVIAPEPAASEEDWTAPFDATPERAPVNILARRIAAVLEDWIGRETVIEKGVRR
AMRPGDVIVLVRKRDAFVNALTRALKRRGNIPVAGADRLVLTSHIAVQDLIALGRFVLLP
EDDLSLAALLKSPLLDLGEEDVFELAARRTEGESLWRRLRQAGAEETSRYHEAVRTLSRY
SGLARELLPHDFYARVLGADGGRRAFLARLGSEVSDILDEFLTFALDHERNGLPGLQAFI
STLEIEAPTVKREQDKERDEVRVMTVHAAKGLEAPVVFLVDGGGEAFVRQQVSDLRFLEK
AQVDHSTLTVPVWRAPGSAPNSLIAADNERLKKLAEEEYRRLLYVGMTRAADRLIVCGYR
GQRQNTDTWHSMVQGTLAQDLKGRGTPRLFRAGSEEWQGIAWREAHVPRDLPTSEGRSEE
SQRPTAGLPTALFTPPAAPRRLPRPLAPSGTTIAIDDPDAEAIVGSALFAGKSAPKFSML
RGAILHRLLQVLPSVDGPERLAAAERYLARSVPRWPEAERRALAGTVMDVLDHADLQPLF
GEHSRAEVSVMGTLKLGVREFAVSGRIDRLAVTGDMVTIADYKTNREIPETPEEIAPVYR
NQLAIYRELLKPLYPGKRFRCVLIFTEGPAIRVLPEPMLDRSLEELATK