Protein Info for SMc02584 in Sinorhizobium meliloti 1021

Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 194 PF00072: Response_reg" amino acids 26 to 134 (109 residues), 81.8 bits, see alignment E=2.1e-27

Best Hits

Swiss-Prot: 100% identical to ACTR_RHIME: Acid tolerance regulatory protein ActR (actR) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K15012, two-component system, response regulator RegA (inferred from 100% identity to smk:Sinme_3396)

Predicted SEED Role

"Dna binding response regulator PrrA (RegA)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0C5S3 at UniProt or InterPro

Protein Sequence (194 amino acids)

>SMc02584 transcriptional regulator (Sinorhizobium meliloti 1021)
MIEKSMPAQNTHAADADLIGPDKSLLIVDDDTAFLRRLARAMEARGFAVEIAESVAEGIA
KAKTRPPKHAVIDLRLSDGSGLDVIEAIRGRRDDTRMIVLTGYGNIATAVNAVKLGALDY
LAKPADADDILAALIQRPGERVEPPENPMSADRVRWEHIQRVYEMCERNVSETARRLNMH
RRTLQRILAKRAPK