Protein Info for SMc02413 in Sinorhizobium meliloti 1021
Annotation: aminotransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 53% identical to ACLR_ACHOB: 2-aminohexano-6-lactam racemase from Achromobacter obae
KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 100% identity to smk:Sinme_2640)Predicted SEED Role
"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)
MetaCyc Pathways
- L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
- L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
- superpathway of arginine and polyamine biosynthesis (14/17 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
- L-ornithine biosynthesis I (5/5 steps found)
- 4-aminobutanoate degradation II (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- superpathway of 4-aminobutanoate degradation (2/3 steps found)
- superpathway of L-arginine and L-ornithine degradation (9/13 steps found)
- 4-aminobutanoate degradation I (1/2 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (7/11 steps found)
- GABA shunt I (1/4 steps found)
- GABA shunt II (1/4 steps found)
- 4-aminobutanoate degradation V (3/7 steps found)
- nicotine degradation I (pyridine pathway) (5/17 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Butanoate metabolism
- Glutamate metabolism
- Lysine biosynthesis
- Propanoate metabolism
- Urea cycle and metabolism of amino groups
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.11, 2.6.1.19
Use Curated BLAST to search for 2.6.1.11 or 2.6.1.19
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92MM4 at UniProt or InterPro
Protein Sequence (437 amino acids)
>SMc02413 aminotransferase (Sinorhizobium meliloti 1021) MPGLYARESRSVSKMAHLRFFPQAVVGGSGAYLTADDGRQLLDFSASWGAASLGHSHPAI REAVGRALSDQAGASYLSSANEACVLLAEKLLSLVPERARGRVWFGHSGSDANETVARIV VAATGRPRILAFHGAYHGGTIGSMGVSGHPAQQGSRAEGLTLVPYPNSYAAGSPEAARDA ALAHLERLFATEVPPEEVAAFFIEPIQSDGGMLVPPDGFFKAVEALCRRHGILIVSDEVK VGLGRSGRFNAFEHSGIEPDIVVFGKGLGGGLPISAVVGPEAIMNHSVAFSLQTVHGNPV CAAAALAVLQTIERDHLILNADRSGKVLREALDRLTARHTLIGDVRGRGLALGIELVTDP ASREPASRQAALTVYRAFQLGLVLYYVGVQSNVLELTPPLTLTPAEAESGVAMLGQALAD VAAGRIDEALLGDFAGW