Protein Info for SMc02171 in Sinorhizobium meliloti 1021

Annotation: periplasmic binding ABC transporter protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 341 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF00532: Peripla_BP_1" amino acids 30 to 257 (228 residues), 58.6 bits, see alignment E=7.5e-20 PF13407: Peripla_BP_4" amino acids 32 to 301 (270 residues), 147 bits, see alignment E=8e-47

Best Hits

Swiss-Prot: 100% identical to FRCB_RHIML: Fructose import binding protein FrcB (frcB) from Rhizobium meliloti

KEGG orthology group: K10552, fructose transport system substrate-binding protein (inferred from 100% identity to sme:SMc02171)

Predicted SEED Role

"Fructose ABC transporter, substrate-binding component FrcB" in subsystem Fructose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92SC8 at UniProt or InterPro

Protein Sequence (341 amino acids)

>SMc02171 periplasmic binding ABC transporter protein (Sinorhizobium meliloti 1021)
MKKTVLSAAFGALAMGVAFASPSQAAEVSACLITKTDTNPFFVKMKEGAAAKAKELGVTL
KSYAGKIDGDSESQVAAIETCIADGAKGILIAASDTQGIVPQVQKARDAGLLVIALDTPL
EPLDAADATFATDNLLAGKLIGQWAAATLGDAAKEAKVAFLDLTPSQPSVDVLRDQGFMI
GFGIDPKDPNKIGDEDDPRIVGHDITNGNEEGGRTAMENLLQKDPTINVVHTINEPAAAG
AYEALKSVGREKDVLIVSVDGGCPGVKNVAEGVIGATSQQYPLMMAALGIEAIKKFADTG
EKPTPTEGKDFVDTGVSLVTDKPVSGVESIDTKTGMEKCWG