Protein Info for SMc02080 in Sinorhizobium meliloti 1021

Annotation: valyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 947 transmembrane" amino acids 536 to 555 (20 residues), see Phobius details TIGR00422: valine--tRNA ligase" amino acids 3 to 925 (923 residues), 1062.4 bits, see alignment E=0 PF00133: tRNA-synt_1" amino acids 15 to 631 (617 residues), 516.6 bits, see alignment E=1.2e-158 PF09334: tRNA-synt_1g" amino acids 44 to 94 (51 residues), 29 bits, see alignment 1.2e-10 amino acids 570 to 634 (65 residues), 30.9 bits, see alignment 3.3e-11 PF08264: Anticodon_1" amino acids 673 to 821 (149 residues), 144.8 bits, see alignment E=4.7e-46 PF10458: Val_tRNA-synt_C" amino acids 879 to 942 (64 residues), 43.8 bits, see alignment 6.5e-15

Best Hits

Swiss-Prot: 100% identical to SYV_RHIME: Valine--tRNA ligase (valS) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01873, valyl-tRNA synthetase [EC: 6.1.1.9] (inferred from 84% identity to ara:Arad_2111)

Predicted SEED Role

"Valyl-tRNA synthetase (EC 6.1.1.9)" (EC 6.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Q37 at UniProt or InterPro

Protein Sequence (947 amino acids)

>SMc02080 valyl-tRNA synthetase (Sinorhizobium meliloti 1021)
MLDKTYDSAAVEPKIAKAWDEADAFRAGVNAKPDAETFTIVIPPPNVTGSLHMGHALNNT
LQDIMVRFERMRGKDVLWQPGMDHAGIATQMVVERQLMERQLPSRRDMGREAFIERVWEW
KAESGGLIFNQLKRLGASCDWSRERFTMDEGLSEAVIEVFVSLYKEGLIYRDTRLVNWDP
KLQTAISDIEVEPVEVNGHLWHLRYPLEEGVTYQHPVAFDEDGNATEWETRNYLVVATTR
PETMLGDTGVAVHPDDVRYKGIVGKHVILPIVGRRIPIVADEYPDPTTGTGAVKMTPAHD
FNDFDVGKRQGLRQVNVLTADGRITIKNNEDFLEGLDHPAALHGAWDRLEGKDRFEARKL
IVEMLEEAGLVDHIEPHKHMVPHGDRGGVPIEPRLTEQWYVDAKTLAKPAIAAVKEGRTN
FVPKNWEKTFFEWMENIQPWCISRQLWWGHQIPAWYGPDGQIFVERNEEEALHAAIQHYI
AHEGPMKAYVEDLLENFKPGEILTRDEDVLDTWFSSALWPFSTLGWPKETPELDKYYQTD
VLVTGFDIIFFWVARMMMMGLHFMKDADGTPVEPFHTVYVHALVRDKNGQKMSKSKGNVI
DPLELIDEYGADALRFTLAIMAAQGRDVKLDPARIAGYRNFGTKLWNATRFAEMNGAISS
EGFIPEAASLTINRWILTELSRTIRDVSEAIEDYRFNEAAGALYRFVWNQFCDWYLELLK
PVFNGDDEAAKRESQACTAYVLDEIYKLLHPFMPFMTEELWEKTTGPGRERTTLLCHAEW
PAAFYADDAAADEINWLIDLVSGIRSVRAEMNVPPAAMAPLVIVGAKALTSERLDRHASA
IKRLARVENIEHASVAPRGSAQIVVGEATACLPLGSLIDLGAEKLRLEKAIAKVDVERER
ILGKLANEKFVANAKPELVEAERERLVELDLQRDSLGVALSRVSEAG