Protein Info for SMc02038 in Sinorhizobium meliloti 1021

Annotation: glycerol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 48% identical to GLDA_ECOL6: Glycerol dehydrogenase (gldA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K00005, glycerol dehydrogenase [EC: 1.1.1.6] (inferred from 100% identity to smk:Sinme_2602)

MetaCyc: 48% identical to L-1,2-propanediol dehydrogenase / glycerol dehydrogenase (Escherichia coli K-12 substr. MG1655)
(R)-aminopropanol dehydrogenase. [EC: 1.1.1.75]; Glycerol dehydrogenase. [EC: 1.1.1.75, 1.1.1.6]; RXN-8632 [EC: 1.1.1.75, 1.1.1.6]

Predicted SEED Role

"Glycerol dehydrogenase (EC 1.1.1.6)" in subsystem Respiratory dehydrogenases 1 (EC 1.1.1.6)

MetaCyc Pathways

acetone degradation III (to propane-1,2-diol) (2/2 steps found)
glycerol degradation II (2/2 steps found)
methylglyoxal degradation III (2/2 steps found)
glycerol degradation to butanol (12/16 steps found)
superpathway of methylglyoxal degradation (6/8 steps found)
aminopropanol phosphate biosynthesis II (3/4 steps found)
glycerol degradation V (1/2 steps found)
superpathway of glycerol degradation to 1,3-propanediol (2/4 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.6 or 1.1.1.75

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92MR2 at UniProt or InterPro

Protein Sequence (364 amino acids)

>SMc02038 glycerol dehydrogenase (Sinorhizobium meliloti 1021)
MARAFGGPNKYIQRAGEIDKLAAYLAPLGKRALVLIDRVLFDALSERIGKSCGDSLDIRF
ERFGGECCTSEIERVRKVAIEHGSDILVGVGGGKTADTAKIVAIDTGARIVIAPTIASTD
APCSAIAVRYTEHGVYEEALRLPRNPDAVVVDSALVAAAPARFLVAGIGDALSTWFEARS
NIESRTDNYVAGGFPATEAGMAIARHCQDVLTRDAVKAKIAVEAGLLTPAVENIIEANTL
LSGLGFENCGCSAAHGIHDGLTVLEEVHGYFHGEKVAFGTLCLLMLENRDRAEIEAMIRF
CRSVGLPTKLADLGIVDDVPAKIGRVAEAACRPGNIIYATPVTITVPAVRDAILALDAFS
RSIH