Protein Info for SMc01934 in Sinorhizobium meliloti 1021
Annotation: prolyl-tRNA synthetase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to SYP_RHIME: Proline--tRNA ligase (proS) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K01881, prolyl-tRNA synthetase [EC: 6.1.1.15] (inferred from 100% identity to smk:Sinme_1082)Predicted SEED Role
"Prolyl-tRNA synthetase (EC 6.1.1.15), bacterial type" (EC 6.1.1.15)
MetaCyc Pathways
- tRNA charging (19/21 steps found)
- pyoluteorin biosynthesis (1/7 steps found)
- ergotamine biosynthesis (4/12 steps found)
- (2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis (2/10 steps found)
- clorobiocin biosynthesis (1/10 steps found)
- superpathway of ergotamine biosynthesis (5/18 steps found)
- pyrrolomycin biosynthesis (1/14 steps found)
- sulfazecin biosynthesis (1/16 steps found)
- phosalacine biosynthesis (4/25 steps found)
- phosphinothricin tripeptide biosynthesis (4/25 steps found)
- colibactin biosynthesis (6/38 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.1.1.15
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92QN2 at UniProt or InterPro
Protein Sequence (442 amino acids)
>SMc01934 prolyl-tRNA synthetase (Sinorhizobium meliloti 1021) MRLSRFFMPILKENPKEAEIVSHRLMLRTGMVRQQSAGIYTWLPLGKRVLDKVNAIIREE QNRSGAIELLMPTLQSAELWQESGRYDAYGKEMLRIKDRQDRPMLYGPTNEEMITDIFRS YVKSYRNLPLNLYHIQLKFRDEIRPRFGTMRSREFLMKDAYSFDLDRAGAEHAYNKMFAA YLRTFDRMGLRAIPMRADTGPIGGNLSHEFIILADTGESEVFCHKDFLGFDIPGEDTNFD DVAGLKTIFDKWTSRYAATSEMHDEAAFGAIAEGERLSARGIEVGHIFYFGTKYSEAMGA KVLGPDGKEHTVHMGSYGIGPTRLVPAIIEASHDDNGIIWPKGIAPFDVVVINMKTGDEA CDAACGKVYSDLGKAGFDVLLDDTDERAGGKFATADLIGVPVQVIVGPRSIANGEVEVKD RKTGARETMTVEAAINKLVAAR