Protein Info for SMc01875 in Sinorhizobium meliloti 1021

Annotation: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00325: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
  • amino acids 14 to 302 (289 residues), 294.9 bits, E=3.4e-92
• PF03331: LpxC
  • amino acids 14 to 286 (273 residues), 330.8 bits, E=3.5e-103

Best Hits

Swiss-Prot: 44% identical to LPXC_PSEHT: UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC) from Pseudoalteromonas haloplanktis (strain TAC 125)

KEGG orthology group: K02535, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC: 3.5.1.-] (inferred from 100% identity to sme:SMc01875)

Predicted SEED Role

"UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (EC 3.5.1.108)" (EC 3.5.1.108)

MetaCyc Pathways

• lipid IV_A biosynthesis (P. gingivalis) (9/9 steps found)
• lipid IV_A biosynthesis (2,3-diamino-2,3-dideoxy-D-glucopyranose-containing) (6/6 steps found)
• lipid IV_A biosynthesis (E. coli) (6/6 steps found)
• lipid IV_A biosynthesis (H. pylori) (6/6 steps found)
• lipid IV_A biosynthesis (P. putida) (6/6 steps found)
• lipid IV_A biosynthesis (Vibrio cholerae serogroup O1 El Tor) (6/6 steps found)
• lipid IV_A biosynthesis (generic) (6/6 steps found)
• superpathway of (Kdo)₂-lipid A biosynthesis (11/17 steps found)
• superpathway of Kdo₂-lipid A biosynthesis (11/25 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.- or 3.5.1.108

Sequence Analysis Tools

See Q92NM5 at UniProt or InterPro

Protein Sequence (322 amino acids)

>SMc01875 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (Sinorhizobium meliloti 1021)
MKVTRMGIELLGFQTTIANPITLKGIGVHSGAEVEITFQPADADVGIVFQRVLAGGRLSE
FRAVSSQVGNTDLCTVLGLSPATSIATIEHVMAAVYALGLDNLLIEVHGAEMPIMDGSSA
PFIEAIEQAGIHSLAEKRRYIRILKPVRIESGASWSEFTPYDGMRFEVEIDFDCPLIGRQ
AWKGDMTPSVFKRELSRARTFGFMRDVERLWAGGFALGSSLENSVVISDDNTVINVEGLR
YTDEFVRHKTLDAVGDLSLAGAPFLGCYRSYRGGHRMNANALKALLSDPTAYEVVETATP
RQRTRSRDMVAVAAPGFAPWSA