Protein Info for SMc01766 in Sinorhizobium meliloti 1021
Annotation: delta-aminolevulinic acid dehydratase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 62% identical to HEM2_BRADU: Delta-aminolevulinic acid dehydratase (hemB) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
KEGG orthology group: K01698, porphobilinogen synthase [EC: 4.2.1.24] (inferred from 100% identity to sme:SMc01766)Predicted SEED Role
"Porphobilinogen synthase (EC 4.2.1.24)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.2.1.24)
MetaCyc Pathways
- adenosylcobalamin biosynthesis II (aerobic) (30/33 steps found)
- superpathway of heme b biosynthesis from glycine (7/8 steps found)
- tetrapyrrole biosynthesis II (from glycine) (4/4 steps found)
- superpathway of heme b biosynthesis from glutamate (8/10 steps found)
- tetrapyrrole biosynthesis I (from glutamate) (5/6 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (26/36 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.2.1.24
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92QU9 at UniProt or InterPro
Protein Sequence (380 amino acids)
>SMc01766 delta-aminolevulinic acid dehydratase (Sinorhizobium meliloti 1021) MRRDALDGRKKCRRRVAGNAGFQPLKAHDKPPSRTIRKEGRGAMNDRTNLVDRITGHRRM RRNRKADWTRRLVRENRLTVDDLIWPIFVVPGSGIVEPIDAMPGVNRMSVDKAVEAAKEA AGLGIPAIATFPNIDMALRDETGSDSLNADNLINQATRAIKKAVPDIGIITDVALDPFTS HGHDGILRGGEIVNDETVEAIARAAVIQADAGSDIIAPSDMMDGRIGAIREALDAACHQN VGIMSYATKFASAFYGPYREAIGTGGLLKGDKKTYYIDPSNGTEAIRDAALDVEEGADML MVKPGLPYLDICWRMKEAFGLPVFAYQVSGEYAQIKAAAANGWIDGERVMLETLLAFKRA GCDGILSYFAVDVARILAKR