Protein Info for SMc01663 in Sinorhizobium meliloti 1021

Annotation: oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 815 PF01266: DAO" amino acids 9 to 373 (365 residues), 219.4 bits, see alignment E=2.7e-68 PF16350: FAO_M" amino acids 376 to 430 (55 residues), 57 bits, see alignment 4.5e-19 PF01571: GCV_T" amino acids 432 to 708 (277 residues), 238.9 bits, see alignment E=1.3e-74 PF08669: GCV_T_C" amino acids 727 to 804 (78 residues), 63.3 bits, see alignment E=3.9e-21

Best Hits

KEGG orthology group: K00315, dimethylglycine dehydrogenase [EC: 1.5.99.2] (inferred from 100% identity to sme:SMc01663)

Predicted SEED Role

"Sarcosine dehydrogenase (EC 1.5.99.1)" (EC 1.5.99.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.5.99.1, 1.5.99.2

Use Curated BLAST to search for 1.5.99.1 or 1.5.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ND3 at UniProt or InterPro

Protein Sequence (815 amino acids)

>SMc01663 oxidoreductase (Sinorhizobium meliloti 1021)
MSNLPSHARVVIIGGGAVGASSLYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSS
WSIMNMQRYSASLYRDLGALVDYPMNYHVTGSIRLGHSKERLQEFKRVVGMGRYQGMDLD
ILTPGEMRSRYPFLETHDLTGALYDPYDGDIDPAQLTQALAKGARDMGAKIIRFCPVTGA
RRERDEWVVETAQGEIRCEYVVNAAGYYAREVGKMFGRDVPMMVMSHQYILFDEIPELAA
WSKEVGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWATPDDPMPEDFSFQLFPDD
LERLEWYLNDAVERVPILGTAGLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGI
CQAGGAGKVLAEWVTEGRTEWDMWSCDPRRYTDYTDQDYCIAKGMEIYGHEYAMHFPKHY
WPAGRGRKLSPIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEAATQTWGREGPWAKRI
EEECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGPITGRVPKPGRIGLAYFADDKGRIL
TEMSVMAIEEDFFFLITAATAQWHDFEWLRKHRPADAAFTLDDVTVKFACQILTGPKSRA
ILAEVSDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGWEIHTKVEDTAAVFDAVWDAG
QKHGLKPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWAKPDFKGKAALERE
KQQGVTKRFVTLTVEAGDCDAPYMSTLWSGGEVVGETTSGNWGYRTGKSIALGMLRADLA
VPGQEVEVEIFGDRFKAIVQPDQPLWDPSNERLKA