Protein Info for SMc01498 in Sinorhizobium meliloti 1021

Annotation: sorbitol/mannitol transport inner membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 276 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 75 to 97 (23 residues), see Phobius details amino acids 108 to 131 (24 residues), see Phobius details amino acids 143 to 163 (21 residues), see Phobius details amino acids 184 to 208 (25 residues), see Phobius details amino acids 240 to 261 (22 residues), see Phobius details PF00528: BPD_transp_1" amino acids 91 to 263 (173 residues), 56.6 bits, see alignment E=1.5e-19

Best Hits

KEGG orthology group: K10229, sorbitol/mannitol transport system permease protein (inferred from 99% identity to smd:Smed_2356)

MetaCyc: 63% identical to polyol ABC-type transporter permease component MtlG (Pseudomonas fluorescens)
7.5.2.M2 [EC: 7.5.2.M2]; 7.5.2.M2 [EC: 7.5.2.M2]; 7.5.2.M2 [EC: 7.5.2.M2]

Predicted SEED Role

"Various polyols ABC transporter, permease component 2" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.M2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92N04 at UniProt or InterPro

Protein Sequence (276 amino acids)

>SMc01498 sorbitol/mannitol transport inner membrane protein (Sinorhizobium meliloti 1021)
MARNVSTGRKLITTVVAWTIGILIFFPILWTFLTSFKTEAQAIASPPVFLFFDWTTENYS
EVQSRSDYLKHFMNSVVVSFGSTLLGLLIAIPSAWAMAFSPTKRTKDVLMWMLSTKMMPP
VGVLVPMYLIFRNWGLLDTRTGLVIVLTLINLPIIIWMLYTYFKEIPGEILEAARMDGAS
LTKEIIYVLTPMAIPGIASTLLLNIILAWNEAFWTLNLSAAKAAPLTAFIASYSSPEGLF
YAKLSAASTMAIAPILILGWFSQKQLVRGLTFGAVK