Protein Info for SMc01135 in Sinorhizobium meliloti 1021

Annotation: protease IV transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 transmembrane" amino acids 19 to 40 (22 residues), see Phobius details TIGR00706: signal peptide peptidase SppA, 36K type" amino acids 51 to 251 (201 residues), 207.1 bits, see alignment E=1.2e-65 PF01972: SDH_sah" amino acids 62 to 153 (92 residues), 22.9 bits, see alignment E=5.9e-09 PF00574: CLP_protease" amino acids 65 to 133 (69 residues), 22.8 bits, see alignment E=1.2e-08 PF01343: Peptidase_S49" amino acids 106 to 253 (148 residues), 137.2 bits, see alignment E=7.2e-44

Best Hits

KEGG orthology group: K04773, protease IV [EC: 3.4.21.-] (inferred from 100% identity to sme:SMc01135)

Predicted SEED Role

"macromolecule metabolism; macromolecule degradation; degradation of proteins, peptides, glycopeptides"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92SJ8 at UniProt or InterPro

Protein Sequence (319 amino acids)

>SMc01135 protease IV transmembrane protein (Sinorhizobium meliloti 1021)
MDELAIADRRSLRRKLSFWRWAAVAVLVAGGLALFAFSGWGDVTERARDHVARVAVTGLI
QDDRELVERLERIADNQSVKALIVTISSPGGTTYGGEVIYKAIRKVAEKKPVVSDVRTLA
ASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDKLGVSLESIKSRPLKAEPSPF
HPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRPEALALADGRIFTGRQALEGKLVDEL
GGDDEIRAFLAERKVSKDLPVLDWEAPSGTLSFGLGSLLAESVKALGYEAFPTMKSLEKT
GLDKLFLDGLVSVWQVEGQ