Protein Info for SMc01051 in Sinorhizobium meliloti 1021

Annotation: nucleoside triphosphate pyrophosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 TIGR00444: MazG family protein" amino acids 13 to 270 (258 residues), 308.1 bits, see alignment E=2.5e-96 PF03819: MazG" amino acids 30 to 103 (74 residues), 110 bits, see alignment E=5.5e-36 amino acids 177 to 240 (64 residues), 30.8 bits, see alignment E=2.9e-11 PF01503: PRA-PH" amino acids 180 to 226 (47 residues), 29 bits, see alignment 1.1e-10

Best Hits

KEGG orthology group: K02428, nucleoside-triphosphate pyrophosphatase [EC: 3.6.1.19] (inferred from 100% identity to sme:SMc01051)

Predicted SEED Role

"Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8)" (EC 3.6.1.8)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.19 or 3.6.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Q82 at UniProt or InterPro

Protein Sequence (277 amino acids)

>SMc01051 nucleoside triphosphate pyrophosphohydrolase (Sinorhizobium meliloti 1021)
MEASRDIQRLLDIMAALRDPETGCPWDIVQTFETIRPYTIEEAYEVADAIERHDMDDLCD
ELGDLLLQVVFHARMAEEAGAFSFGDVVEAITRKMIRRHPHVFARSDADTAEAVKLQWEE
IKQAEKADRRQRRLQRGVSQEEHAGHLGSIQRSFPALVEALKLQERAAKVGFDWSEPEPI
LDKVEEEIGELRQALKDGDLGKVADELGDLIFALVNIGRHVGTDPEMALRGTNTKFRRRF
GHIEKELEAGGETLDAASLERMEELWQAAKAIERQLT