Protein Info for SMc01025 in Sinorhizobium meliloti 1021

Annotation: CTP synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 534 (533 residues), 751.5 bits, E=2.4e-230
• PF06418: CTP_synth_N
  • amino acids 3 to 264 (262 residues), 400.8 bits, E=4e-124
• PF00117: GATase
  • amino acids 301 to 533 (233 residues), 131.9 bits, E=3.5e-42
• PF07722: Peptidase_C26
  • amino acids 367 to 516 (150 residues), 26.5 bits, E=7.7e-10

Best Hits

Swiss-Prot: 100% identical to PYRG_RHIME: CTP synthase (pyrG) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 100% identity to smk:Sinme_1240)

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• superpathway of pyrimidine ribonucleosides salvage (8/10 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-glutamate and L-glutamine biosynthesis (5/7 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Sequence Analysis Tools

See Q92QA0 at UniProt or InterPro

Protein Sequence (542 amino acids)

>SMc01025 CTP synthetase (Sinorhizobium meliloti 1021)
MARYVFITGGVVSSLGKGIAAAALGALLQARGYRVRLRKLDPYLNVDPGTMSPTQHGEVF
VTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTN
EIKNFVTEGNEDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAVYVHLTLMPYIP
AAGELKTKPTQHSVKELQALGIHPDILLVRADREIPEAERRKLSLFCNVRQSAVIQALDV
ASIYDVPIAYHKEGLDNEVLAAFGIEPAPKPRMEAWEDVAHRIRTPEGEVTIAIVGKYTG
LKDAYKSLIEALYHGGIANRVKVKLEWIESEVFEKEDPAPYLEKVHGILVPGGFGERGSE
GKINAARFARERKVPYFGICFGMQMAVVEAARNLAGIEKASSTEFGPTKEPVVGLMTEWV
KGNELEKRSAAGDLGGTMRLGAYRAALKPDTKIAGIYGSPDISERHRHRYEVNVDYKSRL
ESCGLVFSGMSPDGVLPETIEYPDHPWFIGVQYHPELKSRPLDPHPLFSSFIEAALEQSR
LV