Protein Info for SMc00871 in Sinorhizobium meliloti 1021

Annotation: F0F1 ATP synthase subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 transmembrane" amino acids 27 to 48 (22 residues), see Phobius details amino acids 84 to 108 (25 residues), see Phobius details amino acids 114 to 133 (20 residues), see Phobius details amino acids 144 to 167 (24 residues), see Phobius details amino acids 187 to 214 (28 residues), see Phobius details amino acids 221 to 242 (22 residues), see Phobius details TIGR01131: ATP synthase F0, A subunit" amino acids 8 to 244 (237 residues), 224.2 bits, see alignment E=1e-70 PF00119: ATP-synt_A" amino acids 31 to 242 (212 residues), 212.7 bits, see alignment E=3e-67

Best Hits

Swiss-Prot: 100% identical to ATP6_RHIME: ATP synthase subunit a (atpB) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02108, F-type H+-transporting ATPase subunit a [EC: 3.6.3.14] (inferred from 100% identity to sme:SMc00871)

Predicted SEED Role

"ATP synthase F0 sector subunit a"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.14

Use Curated BLAST to search for 3.6.3.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92RM8 at UniProt or InterPro

Protein Sequence (250 amino acids)

>SMc00871 F0F1 ATP synthase subunit A (Sinorhizobium meliloti 1021)
MSNDPTHQFLVNKIVPLEIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQS
VSEMSYEFIASMLREGAGSHGMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFAL
AVFVIGTVLLYGFYKHGFGFLKLFVPQGVPGALLPLVVAIEIISFLSRPISLSVRLFANM
LAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY
LNDAVHPGGH