Protein Info for SMc00671 in Sinorhizobium meliloti 1021

Annotation: histidine transport system permease ABC transporter protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 36 to 64 (29 residues), see Phobius details amino acids 71 to 89 (19 residues), see Phobius details amino acids 95 to 118 (24 residues), see Phobius details amino acids 139 to 166 (28 residues), see Phobius details amino acids 213 to 234 (22 residues), see Phobius details amino acids 254 to 267 (14 residues), see Phobius details PF00528: BPD_transp_1" amino acids 110 to 270 (161 residues), 95.3 bits, see alignment E=2e-31

Best Hits

Swiss-Prot: 47% identical to GBUB_LISM4: Glycine betaine/carnitine transport permease protein GbuB (gbuB) from Listeria monocytogenes serotype 1/2a (strain 10403S)

KEGG orthology group: K02001, glycine betaine/proline transport system permease protein (inferred from 100% identity to smk:Sinme_2756)

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92MC5 at UniProt or InterPro

Protein Sequence (285 amino acids)

>SMc00671 histidine transport system permease ABC transporter protein (Sinorhizobium meliloti 1021)
MFPDSLNLSIRAPVNDFIQALVTNYGWVFKAISGVILKAVLFIEWILRGLPWWLVILAFM
ALAWRSSRRWSLTLAVGALLVTVGVLGLWDLTMQTLALMLMATIVSVVIGVPMGILVAKS
RVVRNITLPVLDVMQTMPSFVYLIPALMLFGLGKVPAILATIIYAVPPLIRLTDLGIRQV
DAEVVEAATAFGGSPGQILFGVELPLATPTIMAGLNQTIMMALSMVVVASMIGARGLGEQ
VLNGIQTLDVGKGLEAGIGIVILAVVLDRITQGFGKPRTEDARNG