Protein Info for SMc00480 in Sinorhizobium meliloti 1021
Annotation: isocitrate dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 76% identical to IDH_SPHYA: Isocitrate dehydrogenase [NADP] (icd) from Sphingobium yanoikuyae
KEGG orthology group: K00031, isocitrate dehydrogenase [EC: 1.1.1.42] (inferred from 100% identity to sme:SMc00480)MetaCyc: 73% identical to isocitrate dehydrogenase subunit (Mycobacterium tuberculosis H37Rv)
Isocitrate dehydrogenase (NADP(+)). [EC: 1.1.1.42]
Predicted SEED Role
"Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)" in subsystem TCA Cycle (EC 1.1.1.42)
MetaCyc Pathways
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/26 steps found)
- superpathway of glyoxylate bypass and TCA (11/12 steps found)
- TCA cycle I (prokaryotic) (9/10 steps found)
- TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
- TCA cycle V (2-oxoglutarate synthase) (8/9 steps found)
- ethene biosynthesis V (engineered) (19/25 steps found)
- cytosolic NADPH production (yeast) (4/5 steps found)
- partial TCA cycle (obligate autotrophs) (6/8 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
- TCA cycle VII (acetate-producers) (6/9 steps found)
- nitrogen remobilization from senescing leaves (5/8 steps found)
- reductive TCA cycle I (7/11 steps found)
- TCA cycle VI (Helicobacter) (5/9 steps found)
- mixed acid fermentation (10/16 steps found)
- methylaspartate cycle (12/19 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glutathione metabolism
- Reductive carboxylate cycle (CO2 fixation)
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.42
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92PG6 at UniProt or InterPro
Protein Sequence (404 amino acids)
>SMc00480 isocitrate dehydrogenase (Sinorhizobium meliloti 1021) MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDA ANAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL VPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHDVYDAPGAGVALAM YNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFDEEFAAQFKAE KLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELAKFSETLERV CVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRKAMAA