Protein Info for SMc00378 in Sinorhizobium meliloti 1021

Annotation: exodeoxyribonuclease VII large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 526 PF13742: tRNA_anti_2" amino acids 16 to 109 (94 residues), 98.3 bits, see alignment E=3.8e-32 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 17 to 359 (343 residues), 397.6 bits, see alignment E=3.3e-123 PF01336: tRNA_anti-codon" amino acids 36 to 111 (76 residues), 48.4 bits, see alignment E=1.1e-16 PF02601: Exonuc_VII_L" amino acids 133 to 406 (274 residues), 296.2 bits, see alignment E=5.6e-92 amino acids 413 to 497 (85 residues), 49.2 bits, see alignment E=8.4e-17

Best Hits

Swiss-Prot: 100% identical to EX7L_RHIME: Exodeoxyribonuclease 7 large subunit (xseA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 100% identity to sme:SMc00378)

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92SR7 at UniProt or InterPro

Protein Sequence (526 amino acids)

>SMc00378 exodeoxyribonuclease VII large subunit (Sinorhizobium meliloti 1021)
MTSFFDSESPSNVAEYSVSELSGSIKRTVEQAFEHVRVRGEISGYRGPHSSGHAYFALKD
DRARIDAVVWKTTFARLKFRPEEGMEVIATGRVTTFPGSSKYQIVIDSLEPAGAGALMAL
IEERKRKLAAEGLFDAGRKRPLPFMPRVVGVVTSPTGAVIRDILHRIADRFPVHVIVWPV
RVQGDGACEEIVAAIEGFNALQPGGSIPRPDVLIVARGGGSLEDLWCFNDEAMVRAAAAS
AIPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLAARLKGAAARQ
MDNRRQTLRSLARALPSLDQLLALPRRRFDEAAAGLGRGLQMNTANKRRSFERNAAHLRP
ELLTARIVDRRQRVLDAVNRAERIVERKVQRGAQRISSADASLRVLPSRLIGQIHRASDR
VSSLGRRGDAAIAADLRRMKSALAAQDRVLQSLSYHSVLQRGFALVRDAAGEPVKQAAAV
HPGMALSLEFADGRIAAVAGEDGTAPQSPKKRPARSGEPTKQGSLF