Protein Info for SMc00339 in Sinorhizobium meliloti 1021

Annotation: adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 665 transmembrane" amino acids 33 to 53 (21 residues), see Phobius details amino acids 343 to 348 (6 residues), see Phobius details amino acids 369 to 393 (25 residues), see Phobius details PF02743: dCache_1" amino acids 170 to 341 (172 residues), 50.7 bits, see alignment E=2.7e-17 PF00672: HAMP" amino acids 388 to 439 (52 residues), 30.9 bits, see alignment 4.2e-11 PF00211: Guanylate_cyc" amino acids 468 to 640 (173 residues), 85.6 bits, see alignment E=5e-28

Best Hits

Swiss-Prot: 100% identical to CYA1_RHIME: Adenylate cyclase 1 (cya1) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 100% identity to sme:SMc00339)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P19485 at UniProt or InterPro

Protein Sequence (665 amino acids)

>SMc00339 adenylate cyclase (Sinorhizobium meliloti 1021)
MLQRSESGFKDIESMQDSNADKPSRTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARS
AAIAGAEDNMDAFVGRLVDRLGALSGDTSALVSLVASVANSFLVPPPERMNDKVAVLREG
IARSPHIDGVYVGYPSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERNDQGKPFDRIL
FLDASGLQFAERHAASNGFDPRTRPWYRAAVNGKAPVAIGPYEMATTGNLGMTISQAHRG
NPQIVIGADVVLDTITDFLSRERLTDDSVSFVLDAVGRPIIHSDSTMMRRIMASKGRDRP
VATPQEDGLIESIRRNPPPAGKATLVEVGNRTYLVTVAPLESALLLSGHRVVVAAPLDEL
LAAANETLVQGLAVSGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFATPIDVSS
HVAEISTLNGAMNRARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTAMFTDIYDF
TTISEGRSPEEVVAMLSEYFDLFSEVVAAHDGTIIQFHGDSVFAMWNAPVADTRHAEHAC
RCALAVEERLEAFNSAQRASGLPEFRTRFGIHTGTAVVGSVGAKERLQYTAMGDTVNVAS
RLEGMNKDYGTSVLASGAVVAQCKDMVKFRPLGTAKAKGRSTALDIYEVVGVVRAVNTTE
AGTAA