Protein Info for SMa2327 in Sinorhizobium meliloti 1021

Annotation: sensor protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 896 transmembrane" amino acids 398 to 419 (22 residues), see Phobius details amino acids 431 to 458 (28 residues), see Phobius details amino acids 478 to 498 (21 residues), see Phobius details PF02702: KdpD" amino acids 25 to 234 (210 residues), 312.4 bits, see alignment E=3.8e-97 PF00582: Usp" amino acids 255 to 368 (114 residues), 29.8 bits, see alignment E=2.5e-10 PF13493: DUF4118" amino acids 403 to 508 (106 residues), 93.8 bits, see alignment E=1.6e-30 PF13492: GAF_3" amino acids 528 to 644 (117 residues), 29.3 bits, see alignment E=3e-10 PF00512: HisKA" amino acids 666 to 731 (66 residues), 50.7 bits, see alignment 4.6e-17 PF02518: HATPase_c" amino acids 775 to 886 (112 residues), 79.9 bits, see alignment E=5.7e-26

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to sme:SMa2327)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92XJ2 at UniProt or InterPro

Protein Sequence (896 amino acids)

>SMa2327 sensor protein (Sinorhizobium meliloti 1021)
MPHNDRDLKSRPDPDALLALAEQGRRGKLTVFLGAAPGVGKTFAMLTRARRLKEEGGDIV
IGLVETHGRGETAALLEGLEVLPRRQVLHNGRTLHEFDLDAALARRPRVILVDELAHTNF
GESRHPKRYQDIEELVDAGIDVWTALNIQHLESLSDVVAHIAGVPVRERVPDTVLNRADD
VLLVDLPPAELIERLKEGKVYLPDNAKRAADRFFRLGNLTALRELALRRTADRVDDQMVD
YLRQNAIEGPWGAAERLLVCIGPDPLSEKVVRTASRLASSLNADWMVVSVERAEAESSGA
MRQLDETFRLAEQLGAETRRIIGNDFVEEILKLARREHATQIVIGTRRHYFPLRLFRRSL
PDALAARAAGIAIHLVTDGSAPAVKPAARRRSTLPDGWGRGVAIATGTAAAATALGLLIE
QFVVLQNISLLFLLAVLVSATYAGYVAAIAAALISILAYNFCFIEPVGTFTVAEPHEVFA
LFVFLAAAMLAGGLASRVREQAKTARRRAAATQALYDFSRKLSGTANAEDVLWAAVTQIH
ATLRRNAALLLPEDGDVRLMAAWPPDTELGLTDTMAGRWAFEKKEAAGNGTGTLPNSPFQ
FRPLMSPHGVVGVFGFLQEDKPLEINEERALAAILDQTAIAVDRARLSRESLDQAAQLEG
EKFLAALLSSISHDLRTPLATITGAVTSLRQLGERMSEESRDDLLKSIEEESGRLTRFVA
NLLDMTRIEAGTVNAKRDWVDVADVVHSAVERARKYFPGRVFETSIAPDLPLIRGDSVLL
GQVIFNLLDNANRFGGDEPVSIYGRREEDEIVLSVTDLGKGIAPADLDRVFDKFFRKGKP
DGRSLGTGLGLSISKGFVEAMDGRIKAESPAMKRRGTRISMRFPVAETGITEKERG