Protein Info for SMa2219 in Sinorhizobium meliloti 1021
Annotation: decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to UBIX_NEIMB: Flavin prenyltransferase UbiX (ubiX) from Neisseria meningitidis serogroup B (strain MC58)
KEGG orthology group: K03186, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX [EC: 4.1.1.-] (inferred from 100% identity to sme:SMa2219)MetaCyc: 55% identical to 2,5-furan-dicarboxylic acid decarboxylase 2 (Cupriavidus basilensis)
RXN-13093
Predicted SEED Role
"3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-)" in subsystem Ubiquinone Biosynthesis (EC 4.1.1.-)
MetaCyc Pathways
- superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (7/12 steps found)
- ubiquinol-8 biosynthesis (early decarboxylation) (4/8 steps found)
- 5-hydroxymethylfurfural degradation (3/10 steps found)
- superpathway of chorismate metabolism (38/59 steps found)
KEGG Metabolic Maps
- 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Ascorbate and aldarate metabolism
- Benzoate degradation via hydroxylation
- Biphenyl degradation
- Fluorene degradation
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Purine metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.-
Use Curated BLAST to search for 4.1.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92XP7 at UniProt or InterPro
Protein Sequence (197 amino acids)
>SMa2219 decarboxylase (Sinorhizobium meliloti 1021) MSSRRLIVGITGASGAAYGIRALELAQAAGVETHLVVSRSALLTLNQELGLQKADLAGQA DMIYPVADIGASIASGSFPTIGMLIAPCSVRTMSEIATGVTSTLMSRAADVALKERRRLV LMLRETPLHLGHIETMGALTRMGAIIMPPVPAFYAKPQSLDEMITHSTARALDLFGIDTG AVKRWSGLKDALAEEAT