Protein Info for SMa1885 in Sinorhizobium meliloti 1021

Annotation: membrane efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 58 to 373 (316 residues), 182 bits, see alignment E=7.1e-58 PF16576: HlyD_D23" amino acids 78 to 280 (203 residues), 43.9 bits, see alignment E=2.7e-15 PF13533: Biotin_lipoyl_2" amino acids 81 to 119 (39 residues), 34 bits, see alignment 2.9e-12 PF13437: HlyD_3" amino acids 191 to 283 (93 residues), 31.5 bits, see alignment E=3.8e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa1885)

Predicted SEED Role

"Cell Processes; Protection responses; drug/analog sensitivity and resistance"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Y51 at UniProt or InterPro

Protein Sequence (382 amino acids)

>SMa1885 membrane efflux protein (Sinorhizobium meliloti 1021)
MSGTRQQGSSDMKRKFLLTAIGLVAAAAGAAFAFVFETPARDAESADPRLAPPLVRVAEA
TRPERAERAFTGTIAARVQSNLGFRVPGKIVERLVDVGQQVKAGQALMRIDETDLRLALT
AKRNAVAAARAVLVQAIADERRYATLVKGGVAATPQRYEQAKAALDTAAAQLAAAEAEAR
VAENETTYSVLVAGADGTVVATLGEPGQVVAAGQAVVQLAHAGLREALVALPETVRPAIG
SEAEASVYGSDGRRGRARMRQISDAADPQTRTYEARYVLDGDAASAPLGATVTISIRNGE
GQSEVAVPVGAVLNDGSRTGVWVVDQASATARFVPIEIKRLGEETASVTGIELGEQVVAL
GAHLLKDGAPVRTELQAEVSNR