Protein Info for SMa1789 in Sinorhizobium meliloti 1021

Annotation: CyaI4 adenylate/guanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1118 PF07647: SAM_2" amino acids 2 to 59 (58 residues), 61.8 bits, see alignment 1.4e-20 PF00536: SAM_1" amino acids 2 to 59 (58 residues), 63.4 bits, see alignment 5.2e-21 PF00211: Guanylate_cyc" amino acids 89 to 262 (174 residues), 72.5 bits, see alignment E=8.5e-24 PF13191: AAA_16" amino acids 283 to 470 (188 residues), 79.7 bits, see alignment E=9.6e-26 PF13401: AAA_22" amino acids 307 to 471 (165 residues), 28.9 bits, see alignment E=3.2e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa1789)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1, 4.6.1.2

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Y97 at UniProt or InterPro

Protein Sequence (1118 amino acids)

>SMa1789 CyaI4 adenylate/guanylate cyclase (Sinorhizobium meliloti 1021)
MDIAAWLRSLGLEEYASAFRDNDIDAQLLLHLKAEDLKELGVASIGHRRKLIDAIADLRD
EDARSSNVSVDRPLPAPTAASPEAGAERRQLTVMFCDLVGSTALASRLDVEDLREIIGAY
QQCVSDTIKRFGGFVAKYMGDGVLVYFGYPQAHEDDAERAVRAGLALIDIVNELELSDPL
QVRIGIATGIVVVGDIVGFGEARERGVIGETPNIAARLQGLAEPDTVVIGERTHHLLGHL
FDFRDLGTLEVKGYSEPIRAYQVLRPSILDSRFEALHGERLTPLVGRENEIEALRHCWQR
AKGIEGQVILLVGEPGIGKSRITVAVLEEIANEQRTHLCYFCSPHHSGSALYPIIRQLER
AAEMSPDDDTSTKLDKLETLLAATSTAAEDCSLVSDLLSLPSSGRFPTFDLSPQQRKSRT
LQALVRQLEALAGREPVVMIFEDVHWIDPTSLELLDRTVERIRMLPVLLVVTFRPEFTPP
WSGQPHVSMMTLGRLGQRDGVALVEHVLGQQDLPAEAIQGIVERTDGVPLYLEEFTKAVA
EMCAEGDHAQSTASSASLGIPATLHASLMARLDRLGAAKNVAQIAAVIGREFSHDLLAAV
APYAATELRAFIDQLTSSGMVFRRGTAADSLYLFKHALVQDAAYNTLLRRPRQQLHGKIA
RTLEELFPGRAAREPEVLAHHFAKAGQAARAIDYWLIAGKQAAQRSANLEAIDHFSRGLK
ALEALPLGSEKDWKELALQTALGTALISVHGYAASQTGAAYARARILCQKFGDAAALHAT
LSGEFVYHFVRGDRAMMRRLTKEARRTAESTGDDAFQLAGHRMDGITAMYDGSFIEASHE
FETILSLYDPDRHRPPPVLYIHDPKISALAYLAILKWILGQSDTARGFAIEALRYAEELK
QANLTAHVRTYAGAGLHELLGETSAVRRHADAIVALADQHSLHYWRLNGLFLRGWAIAQG
ASVEEGLAVMRQNLRARSALGVSWYHVRYLCMLATTLQKSGAAESALAVVAEAKDQAACH
CEHMWDAEVERIEAEMLEVCARSTVECEARFQSALVTARRQSAKSFELRAALGLAKLWAE
HGRGDEARDLLWPLYESFTEGFNTRDLTQARQLLDKLH