Protein Info for SMa1731 in Sinorhizobium meliloti 1021

Annotation: betaine aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to BETB2_RHIME: NAD/NADP-dependent betaine aldehyde dehydrogenase 2 (betB2) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_6150)

MetaCyc: 52% identical to gamma-trimethylaminobutyraldehyde dehydrogenase (Rattus norvegicus)
4-trimethylammoniobutyraldehyde dehydrogenase. [EC: 1.2.1.47]

Predicted SEED Role

"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)

MetaCyc Pathways

choline-O-sulfate degradation (3/3 steps found)
choline degradation I (2/2 steps found)
glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
glycine betaine biosynthesis III (plants) (2/3 steps found)
β-alanine biosynthesis I (1/2 steps found)
β-alanine biosynthesis IV (1/2 steps found)
choline degradation IV (2/4 steps found)
dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
L-carnitine biosynthesis (1/4 steps found)
dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.8

Use Curated BLAST to search for 1.2.1.47 or 1.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YD2 at UniProt or InterPro

Protein Sequence (489 amino acids)

>SMa1731 betaine aldehyde dehydrogenase (Sinorhizobium meliloti 1021)
MQSYQIREMATPLCQPAASHFIDGTFIEDRTGPEILSVNPVDGEIIAKLHGATSCIIEKA
IASAKRAQKEWARKEPAERGRVLSRAADIMRARNRELSVLETRDTGKPISETLVADAASG
ADCLEYFGAIAATLSGDSIQFGEDWVYTRREPLGVCLGIGAWNYPIQIAAWKAAPALACG
NAMIFKPSEVTPLSALKLAEILTEAGLPPGVFNIVQGAGDVGAELATHPAIAKVSLTGSV
KTGARVASAAMAGIRPVTMELGGKSALIVFDDADVEAAVSGAILGNFYSAGQICSNGTRV
FLQRGIREAFLARLLARVAALKIGDPMDEETDIGPLVSAAHRNRVATYVARAEVEGAYQM
APPRKLPPGDAWHEPVVFTNVTDWMTLAREEVFGPVMAVLDFDDEQDVVARANATDFGLA
AGIFTRDLVRAHRLAAELEAGTVWINAYNLTPAGMAFGGIKRSGIGRENGRVAIDHYTQL
KSVFVSMQT