Protein Info for SMa1718 in Sinorhizobium meliloti 1021

Annotation: AdeC4 adenine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 PF01979: Amidohydro_1" amino acids 70 to 356 (287 residues), 84.3 bits, see alignment E=1.6e-27 PF13382: Adenine_deam_C" amino acids 417 to 579 (163 residues), 172.1 bits, see alignment E=1.1e-54

Best Hits

Swiss-Prot: 100% identical to ADEC4_RHIME: Adenine deaminase 4 (ade4) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01486, adenine deaminase [EC: 3.5.4.2] (inferred from 100% identity to sme:SMa1718)

Predicted SEED Role

"Adenine deaminase (EC 3.5.4.2)" in subsystem Purine conversions (EC 3.5.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.2

Use Curated BLAST to search for 3.5.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YE0 at UniProt or InterPro

Protein Sequence (600 amino acids)

>SMa1718 AdeC4 adenine deaminase (Sinorhizobium meliloti 1021)
MSDVREFIRAASGGESKATVAVCGGRLVNVVSEEIYQADVAIYRDRIIAVGDISEYIGPQ
TEIIDAADRYLTPGMIDGHLHVECSKLSLTSFAKAVLPLGTTSIVSGLDQIIVVGGPDAA
REFLDEVRQTPLKVFWGAPCKTPYTMPRSTVGHYFSPKDHRDTHHWPECVGIWETVREFI
QEEDEDVLQAIEIGQANRLPVLGCCPMTRGARLNGYMQSGVRADHESYTPEEMLEKLRAG
MHVVVRESSISHFLSDNLRIVTEMGVKALRRISFCTDDVVASDILSRGHLDNMVRMAMAM
GISPMAAIQMATINGAEALRIDHKVGSISPGRTADILIVNDLRDFRIEAVVANGTVAARD
GRMVVKLVPPQRSAGLLRSVKTTPVTAADIAVPFTGTTPFAEVLAIAVTPEKVFVRTRRD
VRLPVVDGKILADASQNVQYVTVVERYGKTLNRPVAFVSGFNLKSGAIASSTAPDDNNII
CIGADPQDMAIAINHLVANNGGQVVVDKGEVVEFLHLPIGGIVSDIDPAEMAAFELRLDE
AARRLGCDLPWPFMYMFVLQITAIPDYAMTDLGVVDCVNLRIISPLAPDGPAKANTLAAE