Protein Info for SMa1683 in Sinorhizobium meliloti 1021

Annotation: arylsulfatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF00884: Sulfatase" amino acids 34 to 381 (348 residues), 166 bits, see alignment E=1.3e-52 PF14707: Sulfatase_C" amino acids 411 to 514 (104 residues), 31.1 bits, see alignment E=3.1e-11

Best Hits

KEGG orthology group: K01134, arylsulfatase A [EC: 3.1.6.8] (inferred from 100% identity to sme:SMa1683)

Predicted SEED Role

"Choline-sulfatase (EC 3.1.6.6)" in subsystem Choline Transport or Choline and Betaine Uptake and Betaine Biosynthesis (EC 3.1.6.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.6

Use Curated BLAST to search for 3.1.6.6 or 3.1.6.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YF6 at UniProt or InterPro

Protein Sequence (555 amino acids)

>SMa1683 arylsulfatase (Sinorhizobium meliloti 1021)
MNRRLMRSVGAFVASTVLWCTASSPQAQEARPKPNILFIVSDDTGYGDLGPYGGGEGRGM
PTPNIDRLADEGMTFFSFYAQPSCTPGRAAMQTGRIPNRSGMTTVAFQGQGGGLPAAEWT
LASVLKRGGYQTYFTGKWHLGEADYALPNAQGYDEMKYVGLYHLNAYTYADPTWFPDMDA
ETRALFQKVTKGSLSGKAGGEVTEDFKINGQYVDTPVIDGKPGVVGIPFFDGYVEKAAIE
FLDAAAKKPDQPFFINVNFMKVHQPNLPAPEFQHKSLSKSKYADSVVELDTRIGRILDKL
RETGMDKNTLVFYTTDNGAWQDVYPDAGYTPFRGTKGTVREGGNRVPAIAFWPGKIQPGS
RSHDVVGGLDLMATFASAAGVPLPDRDREDKPIIFDSYDMTPVLLGTGESARKNWFYFTE
NELTPGAARVGHYKAVFNLRGDNGQATGGLAVDTNLGWKGAQSYVAIVPQVFDLWQDPQE
RYDVFMNNYTEHTWSLVSISAAIKDLMKTYVEYPPRKLQSMGYDGPIELSKYQMLQSVRE
QFEKEGVRLAMPTGN