Protein Info for SMa1668 in Sinorhizobium meliloti 1021

Annotation: ArcD2 arginine/ornithine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 35 to 54 (20 residues), see Phobius details amino acids 84 to 105 (22 residues), see Phobius details amino acids 122 to 141 (20 residues), see Phobius details amino acids 148 to 173 (26 residues), see Phobius details amino acids 193 to 212 (20 residues), see Phobius details amino acids 230 to 252 (23 residues), see Phobius details amino acids 278 to 307 (30 residues), see Phobius details amino acids 328 to 347 (20 residues), see Phobius details amino acids 354 to 376 (23 residues), see Phobius details amino acids 394 to 411 (18 residues), see Phobius details amino acids 416 to 434 (19 residues), see Phobius details amino acids 446 to 470 (25 residues), see Phobius details TIGR00905: transporter, basic amino acid/polyamine antiporter (APA) family" amino acids 2 to 473 (472 residues), 510.1 bits, see alignment E=3.1e-157 PF13520: AA_permease_2" amino acids 5 to 413 (409 residues), 212.7 bits, see alignment E=9.6e-67 PF00324: AA_permease" amino acids 13 to 426 (414 residues), 62.3 bits, see alignment E=3.8e-21

Best Hits

Swiss-Prot: 53% identical to ARCD_PSEAE: Arginine/ornithine antiporter (arcD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03758, arginine:ornithine antiporter (inferred from 100% identity to smk:Sinme_6103)

Predicted SEED Role

"Arginine/ornithine antiporter ArcD" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation or Polyamine Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YG6 at UniProt or InterPro

Protein Sequence (473 amino acids)

>SMa1668 ArcD2 arginine/ornithine antiporter (Sinorhizobium meliloti 1021)
MAQKLSLFALTGMVVGSMVGAGIFSLPRTFGVATGPFGAIIAWCIAGGGMYMLARVFQSL
AERKPDLDAGVFAYAKEGFGDYPGFLSAFGYWIGSCIGNVSYWVLIKSTLGNFFPVFGDG
NTVVAILFASVGIWLFHFMILRGIQQAAFVNTVVTVAKVIPIIAFIIILFFFFKLDLFRL
NFWGGEGMPEATLLQQIQATMLATVFVFIGIEGASNYSRYAQARSDIGTATIMGFIGVSA
LMVLVTLLPYAALTRPEIAAMSQPSMAGVLAAVVGPWGAVFISIGVIVSVLGAYLAWSLV
CAEVLYVAARTDDMPRLFGTENQNKVPAAALWLTNIVVQLFVISTYWSQDAFALMLNLTS
SMSLIPYMFVAAFGFMLAQRAETYEVRPRERTRDLIIASIAAVYTFFMIVAGGIKFVLLS
ALLYAPGTILYFWARRERGKRVFNTSIDWLIFATAVIGCFAAIIGLSTGYLTI