Protein Info for SMa1600 in Sinorhizobium meliloti 1021

Annotation: Potassium efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 584 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 32 to 50 (19 residues), see Phobius details amino acids 57 to 77 (21 residues), see Phobius details amino acids 86 to 107 (22 residues), see Phobius details amino acids 113 to 135 (23 residues), see Phobius details amino acids 148 to 171 (24 residues), see Phobius details amino acids 197 to 218 (22 residues), see Phobius details amino acids 238 to 255 (18 residues), see Phobius details amino acids 260 to 279 (20 residues), see Phobius details amino acids 291 to 310 (20 residues), see Phobius details amino acids 315 to 339 (25 residues), see Phobius details amino acids 346 to 368 (23 residues), see Phobius details amino acids 380 to 399 (20 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 16 to 396 (381 residues), 164.5 bits, see alignment E=3.4e-52 PF02254: TrkA_N" amino acids 436 to 549 (114 residues), 97.1 bits, see alignment E=8.9e-32

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 100% identity to sme:SMa1600)

Predicted SEED Role

"TrkA-N:Sodium/hydrogen exchanger" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YK4 at UniProt or InterPro

Protein Sequence (584 amino acids)

>SMa1600 Potassium efflux protein (Sinorhizobium meliloti 1021)
MPHTPLIATLVAGLGLAFILGTLANRLRLSPLVGYLLAGVLIGPFTPGFVADQALARQLA
ELGVILLMFGIGLHFSLHDLLSVRTIAVPGAFGQMALVTSLGFIVTQAIGWPIGAGLVFG
LALSVASTVVVLRALQEKRQLETDGGRIAVGWLVVEDVAMILALVLLPAFADVLGGTANR
AEPENSGMLTFFEPHTISGALGLTLAKLAAFFALMAIVGRRVIPAILHYVAHTGSRELFR
LAVLAIALGVAFGAAELFGVSFALGAFFAGMILAESQLSQRAAQETLPLRDAFAVLFFVS
VGMLFNPMILVEQPLLVAATFLIIVIGNAAAASAIAVMFGYSLPIAVTLGLSLAQIGEFS
FILAGLGVELNLLPETGRDLVLAGAILSILINPLLFAGLDRLMPRLENRAPVRTEEEGRI
DITPKLTTTSLTDHAILVGYGRVGRLVAETLQNAGQPYLIVEERQVVADQLRAGGVDVIS
GNAAQPGLLEAANVNSAKWLISAIPNPFESGNFIEHARATNPKLEIIARAHSDAEVEYLK
RLGANLIIMGEKEIARSISEHILSNINAPDTTTPSDSESRLTSE