Protein Info for SMa1591 in Sinorhizobium meliloti 1021

Annotation: CyaI3 adenylate/guanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1159 PF00536: SAM_1" amino acids 30 to 89 (60 residues), 58.6 bits, see alignment 1.3e-19 PF07647: SAM_2" amino acids 32 to 89 (58 residues), 48 bits, see alignment 2.3e-16 PF00211: Guanylate_cyc" amino acids 114 to 280 (167 residues), 69.9 bits, see alignment E=4.4e-23 PF13191: AAA_16" amino acids 310 to 498 (189 residues), 90.3 bits, see alignment E=4.3e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa1591)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1, 4.6.1.2

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YL0 at UniProt or InterPro

Protein Sequence (1159 amino acids)

>SMa1591 CyaI3 adenylate/guanylate cyclase (Sinorhizobium meliloti 1021)
MRSFLLGGVRPRDFWSMLKNLALRVDGEGAMDIGAWLRDQGLGQYEGTFRQNDIDPEVLR
HLTAEDLIGVGVASVGHRRKLLAAIAALREVAEQPSGAAGFGATPVINPEAERRQLTVMF
VDLVESTRLSSRLDPEEMGELLRGYQRAVAGAIARFEGHVAKYMGDGVLAYFGYPRAHED
EAERAVRAGLAAIDAVRKLQPPHGETLEARVGIATGLVVVGELIGEGAAREETVIGETPN
LAARLQSVAEPGAVVVASATRQLIGGLFDLAELGFHPLKGFAASIPAWRVLGESSAESRF
EAFHGASLTPLVGREHDIGLLLKRWEAVKKGKGRVVLLAGEPGIGKSRLVRALRRRLEGE
PHTTVSHYCSPYHQTSPLYPVIRLLERAAGFAAEDPPEVKLSKLEALLTQSIEEVADAAP
LLAALLSVPADDRYQPLELSPHRQKKRMLEVLVDQLIGLAARQPILAVYEDVHWADPTSL
ELLDLVVDRVQDSPVLVLITFRTEFLPPWTRYPHVTVLTLSRLSRRQGAEMVDRLTGRRA
LPTEVLDQIVAKTDGVPLFVEELTRAILETSLLKAEGDHYALARPLSAISIPATLHESLL
ARLDRLAPAREVMQVAAAIGREFSHELLVTAAPLQASEVEEALEDLIASGLVFRHGTPPQ
LTYSFKHALVRDAAYATLVRTKRQRLHAAIATAIEQRFPEMVQTQPELLAQHYAEAGRLE
PAVNYWLRAGQAEIARSATTEAISHLTRGLELLEGLPDDAARLRKELELQVALSVALMTA
KGWAAPEVGRANARARNLCERLGDKSRLFPVLYGDWVFHVVRAELEAGRKAGEELLRRAQ
EEREVSAEIVGNRIAGTGAFLRGEIANAREYLERSLALYDPQQHRALAFLFAQDPRVAGL
SVLSLTLFALGYPEQAQARSNEALADARELSHSNTLGFALLYGCILSQLRGDWREARDRA
GSLITLARAQGSPHFLGAGKILQGWTLGQTGELPAASTKVQEGLASWQMTGARFLVPYFL
SLLARVETQSAGAKRALDLLTDALQRARETGERWFEAELHRLTGELMLQLPAFDRAEGEA
RLQHAVELARGQGADLWELRAATSLARLRIGQNRFGDVHHLLAPLCGKFAEGFATTDLQS
AQRLLREAAGFDGAIKSSD