Protein Info for SMa1558 in Sinorhizobium meliloti 1021

Annotation: Sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 708 PF01627: Hpt" amino acids 11 to 106 (96 residues), 45.3 bits, see alignment E=1.7e-15 PF02518: HATPase_c" amino acids 300 to 434 (135 residues), 62.2 bits, see alignment E=1.3e-20 PF01584: CheW" amino acids 440 to 569 (130 residues), 59.8 bits, see alignment E=4.6e-20 PF00072: Response_reg" amino acids 592 to 694 (103 residues), 93.2 bits, see alignment E=2.4e-30

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 100% identity to sme:SMa1558)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YM5 at UniProt or InterPro

Protein Sequence (708 amino acids)

>SMa1558 Sensor histidine kinase (Sinorhizobium meliloti 1021)
MITPEELDPGLLTMFTQEVRERASEMENAVLAIEASGDADRKRHLQEQLLRGAHSLKGAA
GLLQVRGVETICHWMEEILSMAANVGLVLERSRLDLLLSAADAIRDAANLLESGEIPSPA
HGQDVVEKLKAVATAGSDDGLKEAHHHPPMAEPEIAIRATDTDGSMRVSAARLDALLYRS
GEMLTFNAVMRRHAEQASSLREEARKMRAPGSDPTGQVASVEGGLRQLAAFLRQDVRLMQ
SAVTALDEEIRLARTQPFAEACKGLGRIVRDVAAASGKRAELEISGGELEVDRSIVSALQ
DSLRHLVRNAVAHGIQTPEERRTAGRPEKGRILVSAAMRGNRMEVRVEDDGRGLNLALLS
AATGESTHGKQAEADILRRVFEPGVSTSATVTSLSGRGIGLDIVKRNVEKLRGAVDVSQV
PTGGAAFTLTLPLTLATVRVLEVLAGGHVFTIDTTSVQRVIRIDRGDFTLIEGRNFVRTP
AGPMPFVDVSLWLRLQPNRSPASETTPAVVVDSPSGSTAVLVDEITGEQELLARSLGPRL
ANVRRYSRGMVLPDGRIALLLNVAALAEAAAEVRPRNEVGARPSVAAARRKVLVVDDSKY
VRTLVKLILEGAGYDVTMATDGTEALKQLRDHGADVVVADVDMPSMNGFELTRAIRQSDR
FTGTPVVLVTGRESLEDKVKGLRAGANAYLRKDQFDAHDFLETMRQVV