Protein Info for SMa1538 in Sinorhizobium meliloti 1021

Annotation: monovalent cation/H+ antiporter subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 29 to 48 (20 residues), see Phobius details amino acids 68 to 88 (21 residues), see Phobius details amino acids 95 to 112 (18 residues), see Phobius details amino acids 118 to 136 (19 residues), see Phobius details amino acids 147 to 172 (26 residues), see Phobius details amino acids 183 to 205 (23 residues), see Phobius details amino acids 213 to 235 (23 residues), see Phobius details amino acids 241 to 259 (19 residues), see Phobius details amino acids 266 to 285 (20 residues), see Phobius details amino acids 297 to 317 (21 residues), see Phobius details amino acids 332 to 353 (22 residues), see Phobius details amino acids 372 to 393 (22 residues), see Phobius details amino acids 414 to 437 (24 residues), see Phobius details amino acids 453 to 474 (22 residues), see Phobius details amino acids 565 to 585 (21 residues), see Phobius details PF00361: Proton_antipo_M" amino acids 111 to 380 (270 residues), 137.8 bits, see alignment E=2.2e-44

Best Hits

KEGG orthology group: K05568, multicomponent Na+:H+ antiporter subunit D (inferred from 100% identity to sme:SMa1538)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain L (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YN5 at UniProt or InterPro

Protein Sequence (586 amino acids)

>SMa1538 monovalent cation/H+ antiporter subunit D (Sinorhizobium meliloti 1021)
MIDFVHPALIFILGALPIAFLTGPVRKAYLVLIPVLAIVAVTAIEPGSYGETQFLGQDIL
VAKADKLSIVFATVFTIMALIGTVYALHLSGAGQHVAAFVYVGSALGVVFAGDYLTLYLF
WEGMAFASAYLVFAQGGRQAIRAAFRYLMVHVTGGVVLLGGILLHGAAAGSLLFGPVEGP
LGAGAYLILAGFLLNAAVPPLNAWLTDAYPEATVTGAVFMSAFTTKTAVYVLARAFPGIE
LLVWLGTVMALYGVIYAVLENDCRRLLAYHIVSQVGYMVAGIGIGTELAVNGATSHAFAH
ILYKGLLFMGAGAVIYVTGRRKLTELGGLYKAMPLTVALYMIGAFAISAFPFFSGFVSKS
MVVAAAGQDHRALVMLALTMASSGTFLHTGLKLPYYMFFGTDRGLQAREPPGNMLAAMGM
AAALCIAIGVFPGPLYALLPYPVVFEPYTGVHVTESLGILMFTALGFVIFLRALDPENTI
SLDTDWFYRKGARAFMWFAERPLARYEKAVSDVSETTVLPFLHGSARTGMRLDLNGVDGV
VNGVARSILEGGGVLRRLQTGVITHYVLAMIAGLIAAILVFAVVWR