Protein Info for SMa1535 in Sinorhizobium meliloti 1021

Annotation: NuoN2 NADH I chain N

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01770: proton-translocating NADH-quinone oxidoreductase, chain N
  • amino acids 12 to 468 (457 residues), 530.6 bits, E=2.1e-163
• PF00361: Proton_antipo_M
  • amino acids 126 to 418 (293 residues), 266.7 bits, E=1.3e-83

Best Hits

Swiss-Prot: 100% identical to NUON2_RHIME: NADH-quinone oxidoreductase subunit N 2 (nuoN2) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00343, NADH dehydrogenase I subunit N [EC: 1.6.5.3] (inferred from 100% identity to smk:Sinme_6030)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain N (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

See P56911 at UniProt or InterPro

Protein Sequence (479 amino acids)

>SMa1535 NuoN2 NADH I chain N (Sinorhizobium meliloti 1021)
MTAAALLQWALASVPEIIVVTGACVLLIVGELVRKGRDDLLLWASVAIVLLAAVATLMLA
GEMRPAYAGMFISDRFAVFFKLVFYLATILTFFLSRKYAEIEGIGRSEYYVLLLFALVGM
MIMASAIDLLSIYVGLELMVLCTYVLTGFLRKERRSNEAALKYVILGAVSTAIFLYGVSL
IYGLTGTTQLDRMAEAVSGGPLDPALLLAVVFIVAGLVFKIGAVPFHMWVPDVYEGAPTT
ITAFMSVAPKAAGFAVILRVFLNPLVEASNAWIIVAAIAVATMALGSFVALVQDNFKRLL
AYSSIAHAGFAIFGVVAGGQDGIASVMLYLLIYTFMNLGIFGAVIMMRNGDFSGEVIEDY
AGFAKFHPGLALLMLLYLFSLAGIPPTAGFFAKFYVLVALVERGFVALAVIAVLLSVVSA
YFYIRIVMVIYMREPERAFEPALTPLVSATLAFTAAGTIGIGLFPAWFLRLAQQSAFGG