Protein Info for SMa1465 in Sinorhizobium meliloti 1021

Annotation: ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 251 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 100 to 131 (32 residues), see Phobius details amino acids 170 to 204 (35 residues), see Phobius details amino acids 217 to 242 (26 residues), see Phobius details PF00528: BPD_transp_1" amino acids 72 to 245 (174 residues), 82.3 bits, see alignment E=2e-27

Best Hits

Swiss-Prot: 48% identical to OSMY_SALTY: Osmoprotectant import permease protein OsmY (osmY) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05846, osmoprotectant transport system permease protein (inferred from 100% identity to smk:Sinme_5993)

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YR4 at UniProt or InterPro

Protein Sequence (251 amino acids)

>SMa1465 ABC transporter permease (Sinorhizobium meliloti 1021)
MSALVSPAAPQQRRRIETAPLIVLIVLAGTVALLWWSGMAEEILAYSDDISYLTVQHLEL
VAWAGGLAILVAVPVGIVLSRPAFRLVSEAVMQVFNIGSTVPTLAILALSMTLLGIGTVP
AVFGLWAATLLPIVRNTYAGLRAVPPHLVEAATGMGMTPRQVLWRVELPNALFVIFGGIR
TALAICVGSAPLVFLIGAGGLGELIFTGISLDELPMMMAGAIPTAMLAVLVDFIVGQIQY
YLVPRGINPLR