Protein Info for SMa1459 in Sinorhizobium meliloti 1021

Annotation: Dehydrogenase, malate/L-lactate family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 43% identical to COMC_CHRSD: (2R)-3-sulfolactate dehydrogenase (NADP(+)) (comC) from Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)

KEGG orthology group: None (inferred from 100% identity to sme:SMa1459)

MetaCyc: 43% identical to R-sulfolactate oxidoreductase (Chromohalobacter salexigens DSM 3043)
RXN-11690 [EC: 1.1.1.338]

Predicted SEED Role

"Ureidoglycolate dehydrogenase (EC 1.1.1.154)" in subsystem Allantoin Utilization (EC 1.1.1.154)

MetaCyc Pathways

sulfolactate degradation I (1/3 steps found)
allantoin degradation IV (anaerobic) (5/9 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.154 or 1.1.1.338

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YR7 at UniProt or InterPro

Protein Sequence (334 amino acids)

>SMa1459 Dehydrogenase, malate/L-lactate family (Sinorhizobium meliloti 1021)
MTPVETSWEEIEAVCLEALTLHGAAAETARAVAGAITRAEADGNRVCGLYYLPIFCRHLA
IGKVDGEAVPEVTTRGVTVTVDARSGFAHPAIAAGTPALIDLARQAGLAAMAVRNSYNCL
ALGHHVRPLADAGLIGICVSNAPASVAPPGATRALFGTNPLAFAVPSKEGAPTIVVDQSM
SAVTKTEMILRRDRGEAIPIGWAQDGNGQPTTDAATGLEGSLLPAGGRKGANIALLVEVL
AAALTGSALSTEASAFGNEEGGPPHVGQFLIAIDPDHFAAGHFSEAMDNLVASHDAAGVR
LPGHFGRKQPVCVDADLWKKAVLLSKSKNRQKPG