Protein Info for SMa1447 in Sinorhizobium meliloti 1021

Annotation: Permease, MFS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 transmembrane" amino acids 23 to 51 (29 residues), see Phobius details amino acids 58 to 76 (19 residues), see Phobius details amino acids 88 to 106 (19 residues), see Phobius details amino acids 112 to 134 (23 residues), see Phobius details amino acids 146 to 170 (25 residues), see Phobius details amino acids 179 to 198 (20 residues), see Phobius details amino acids 257 to 277 (21 residues), see Phobius details amino acids 290 to 311 (22 residues), see Phobius details amino acids 321 to 339 (19 residues), see Phobius details amino acids 345 to 366 (22 residues), see Phobius details amino acids 378 to 401 (24 residues), see Phobius details amino acids 406 to 427 (22 residues), see Phobius details PF07690: MFS_1" amino acids 36 to 354 (319 residues), 114.2 bits, see alignment E=6.5e-37 amino acids 296 to 428 (133 residues), 42.6 bits, see alignment E=3.8e-15 PF00083: Sugar_tr" amino acids 64 to 436 (373 residues), 122 bits, see alignment E=3.2e-39

Best Hits

KEGG orthology group: K08369, MFS transporter, putative metabolite:H+ symporter (inferred from 100% identity to sme:SMa1447)

Predicted SEED Role

"Niacin transporter NiaP" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YS3 at UniProt or InterPro

Protein Sequence (437 amino acids)

>SMa1447 Permease, MFS (Sinorhizobium meliloti 1021)
MTTITVDDALDRAGTGTYQRRLMAIFGLVWAADAMQVLAVGFTAASIAATFGLTVPQALQ
TGTLFFLGMLFGAAGFGRLADRIGRRRVLIATVACDAVFGLLSVFAQDFTVLLLLRFLTG
AAVGGTLPVDYAMMAEFLPARNRGRWLVMLEGFWAVGTLIVALAAWAASLAGVADAWRYI
FAVTAIPALIGVGLRFLVPESPLYLLRLGKTSEAKAIVDEILVVNGKMRLGAGASLVPPP
PTASAGIFSADLRKRSLMILAIWFLVSISYYGVFTWMPPRLAGEGFGFVRGYGFLVVLAL
AQIPGYALAAYGVEKWGRRPTLIGFCLLSALGCLLFVAAGTAMLIGVSLLIMSFALLGTW
GALYAYTPELYPTASRATGMGAAGAMARLGGLLAPSLMGLVVAQSFGLAIGIFAGLLLVA
AVAAFLIDAETRRVSLA