Protein Info for SMa1410 in Sinorhizobium meliloti 1021

Annotation: oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 38% identical to DKGB_ECO57: 2,5-diketo-D-gluconic acid reductase B (dkgB) from Escherichia coli O157:H7

KEGG orthology group: K06222, 2,5-diketo-D-gluconate reductase B [EC: 1.1.1.274] (inferred from 100% identity to sme:SMa1410)

MetaCyc: 38% identical to methylglyoxal reductase DkgB (Escherichia coli K-12 substr. MG1655)
Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]; RXN0-7020 [EC: 1.1.1.91, 1.1.1.346]; Aldehyde reductase. [EC: 1.1.1.91, 1.1.1.346, 1.1.1.21]

Predicted SEED Role

"oxidoreductase, aldo/keto reductase family"

MetaCyc Pathways

methylglyoxal degradation III (2/2 steps found)
superpathway of methylglyoxal degradation (6/8 steps found)
ketogluconate metabolism (5/8 steps found)
L-ascorbate biosynthesis VIII (engineered pathway) (4/7 steps found)
D-arabinose degradation V (1/3 steps found)
L-arabinose degradation II (1/3 steps found)
detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
superpathway of pentose and pentitol degradation (21/42 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.21 or 1.1.1.274 or 1.1.1.346 or 1.1.1.91

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YU2 at UniProt or InterPro

Protein Sequence (277 amino acids)

>SMa1410 oxidoreductase (Sinorhizobium meliloti 1021)
MGGPMSVYFEKSYQRGFGTYPLKGEPLKAAVREAITVGYRAFDTAQMYGNEAETGEALAE
SGLARDELCITTKVHPDNYSEEAFLPSVEASLKALRVDQADVLMLHWPEINGENARSLRL
LQKAFDIGLARNIGVSNYTAPMMREAQSIVEAPLVTNQVEFHPLIDQSRLLDAAEETKIA
LSSYCSVARGEVFKHPVFAEIGARYGKTAAQTVLRWILQKGVSMNTMSTKPENIRANFEI
LDFALSPHDMKRIDAMNATNYRILKAGMLPWVPDWDR