Protein Info for SMa1269 in Sinorhizobium meliloti 1021

Annotation: NorD accessory protein for nitric oxide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 transmembrane" amino acids 110 to 127 (18 residues), see Phobius details PF00092: VWA" amino acids 444 to 606 (163 residues), 36.9 bits, see alignment E=4.6e-13 PF13519: VWA_2" amino acids 445 to 557 (113 residues), 27.5 bits, see alignment E=4.1e-10

Best Hits

Swiss-Prot: 67% identical to NORD_BRUA2: Protein NorD (norD) from Brucella abortus (strain 2308)

KEGG orthology group: K02448, nitric oxide reductase NorD protein (inferred from 100% identity to sme:SMa1269)

Predicted SEED Role

"Nitric oxide reductase activation protein NorD" in subsystem Denitrification

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Z18 at UniProt or InterPro

Protein Sequence (631 amino acids)

>SMa1269 NorD accessory protein for nitric oxide reductase (Sinorhizobium meliloti 1021)
MLDFLELEETVGRAWHRLIGNTRTWPRFPDEAVRLEDVQPVLAVYFRGLGGERTVQIAPA
RGRTSAHRLRLRQRMGLGEEKLVQPARDHATLMLPAEFDLFPLRRLNRDLYFWLAAMMAV
MPLKPVGAADPLSRDLALLARAGETVKSVLATYPAMRQRYRRLCRAVLNVRQRRSLPSVE
QRVENQILSMLRAGAGLNDDVPPIIFPRCGPPGYLPMLPVPLWPDALLREETERRNGEDE
PARGGDRAEGSETTRHMATREAQRQSERSPFILNRFEKILAMAEMVNVGRPADDSNDHDA
SAADELDDMTLGERQGRPAARFRFDLDLPPEALDRTPLTAELTYPEWDYRRGSYLKDHCR
VLAAPVSAEGAAGETDPATKSLIRRVRRRFEVLRPRHEMLRAQIDGADLDLDAVVRARTD
LRAGGQGSDRIHMMSRPQAHDLAVTILVDVSLSTDAWFDDLRVLDVEKQALQVLAHGLSA
CGDAHEILTFTSRRRDWVRIETVKAFDEAMSATIEARIAALKPGYYTRIGAAIRHAAAGL
VERPNRRKLLIVLTDGKPNDVDHYEGRFALEDSRRAVGEARRSGISVFGVTVDREAKSYL
PVIFGQNGYAVVSNIGRLPAALPAIYRGLVS