Protein Info for SMa1163 in Sinorhizobium meliloti 1021

Annotation: Cation transport P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 45 to 64 (20 residues), see Phobius details amino acids 70 to 92 (23 residues), see Phobius details amino acids 101 to 127 (27 residues), see Phobius details amino acids 266 to 285 (20 residues), see Phobius details amino acids 291 to 315 (25 residues), see Phobius details amino acids 600 to 620 (21 residues), see Phobius details amino acids 626 to 644 (19 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 100 to 642 (543 residues), 511.7 bits, see alignment E=4.5e-157 TIGR01494: HAD ATPase, P-type, family IC" amino acids 123 to 619 (497 residues), 213.5 bits, see alignment E=6.6e-67 PF00122: E1-E2_ATPase" amino acids 151 to 320 (170 residues), 159.4 bits, see alignment E=1.1e-50 PF00702: Hydrolase" amino acids 337 to 554 (218 residues), 92.4 bits, see alignment E=7.7e-30 PF01814: Hemerythrin" amino acids 665 to 791 (127 residues), 29.1 bits, see alignment E=1.9e-10

Best Hits

KEGG orthology group: K01552, [EC: 3.6.3.-] (inferred from 100% identity to sme:SMa1163)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Z60 at UniProt or InterPro

Protein Sequence (799 amino acids)

>SMa1163 Cation transport P-type ATPase (Sinorhizobium meliloti 1021)
MRDIAQNQDNGSGIQYSSRDLLESTLTRSRDFAPIWQGGELGKRLLLALIAVAMLAGIVT
WLAGRPDLSAASWAAGTAVILASLLTEIAISLGRKEFGLDLIAALAMGGALILGEYLTGT
IVALMYTGGEALEDFAQRRARRELTALLNRVPRTAVRYADGQLQEVSIEELNPGDRILIR
RGEVVPVDGSVMDGIAVLDESALTGEAMPIRRRSGEPVTSGTTNAGDAFEMVASSAASDS
TYAAIVRLVEAAKAAKAPIVRLADRYALGFLAVTLLLAGGAWAISGEPVRALAVLVIATP
CPLILAVPVAIIAGVSRCAGKGVLVKGGGALEMLARIKTVILDKTGTITDGRAHLIELKS
RTDLDPLEVLRLAASLDQGSHHVIARALVAAARERGLQLVAPSGTRESAGSGVSGNIDGH
EIAVGGWDFISERIDETAFSRDIRTWIRRDGVVSVLAAMDGVLAGAFLLADEVRPEVGSV
LRQLREAGVRRIVLATGDRTELAESLQSFLRLDNVAAELKPEDKTRIVEAERAAGPVMMV
GDGVNDAPALAAADVGVAMGARGAAASSEAADVVILVDRLDRLVSAIRIAHRSRGIALQS
VYMGMALSAAGMVAAAFGYLTPVQGALLQEAIDIVAILNALRALGDPMRGWRKTTRLEHA
ELLKLEAEHRALMDVVDEIRHTSARIQDLPEDEVRNQLAHLDTLLRQRLLPHERQDDEEV
YPRLRRQAGAPDAFAGMSRTHMEIQRQVHSLTSLRQAFGEHASGPAQRYEIQRLLHGLEA
ITRLHFAQELEIYRSLEHE