Protein Info for SMa1146 in Sinorhizobium meliloti 1021

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 899 PF02629: CoA_binding" amino acids 12 to 103 (92 residues), 30.1 bits, see alignment E=2.7e-10 PF13380: CoA_binding_2" amino acids 14 to 134 (121 residues), 73.3 bits, see alignment E=9.5e-24 PF13607: Succ_CoA_lig" amino acids 151 to 287 (137 residues), 181.7 bits, see alignment E=2.3e-57 PF19045: Ligase_CoA_2" amino acids 299 to 452 (154 residues), 43.4 bits, see alignment E=1.5e-14 PF13549: ATP-grasp_5" amino acids 481 to 705 (225 residues), 261 bits, see alignment E=3.1e-81 PF13302: Acetyltransf_3" amino acids 738 to 874 (137 residues), 39.6 bits, see alignment E=3.4e-13 PF00583: Acetyltransf_1" amino acids 775 to 874 (100 residues), 43.9 bits, see alignment E=1.1e-14

Best Hits

KEGG orthology group: K09181, hypothetical protein (inferred from 100% identity to sme:SMa1146)

Predicted SEED Role

"Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92Z73 at UniProt or InterPro

Protein Sequence (899 amino acids)

>SMa1146 hypothetical protein (Sinorhizobium meliloti 1021)
MSIRNLHHALDPTSLAIIGASDRDGSLGRVVIENVIRAGFEGEIWPINPKHDQVAGHRCY
RRVADVPGVPDLAVIVTPPQTVPALIHDLGIRGTRAAVIITAGISADQDLRQAMLDAAKP
FLLRIIGPNTVGLIVPSAKLNASFAHLQAQPGGIALLSQSGAIATSLIDWAADNDVGFSK
VVSLGDMADADAGDFLDLLAGDPETHAIVMYLEAISNPRKFLSAARAAARVKPIVAIKAG
RHAEAAKAAATHTGALSGADRVVDAALRRAGILRIEGLGELFDATETIARFPPLEHSRVA
IVTNGGGAGVLAVDRLIDFGCALADLSPETVGTLDRNLPANWSRANPVDIIGDAPPHRYK
TAVETIVRDVGVDILIVMNCPTGLASPVDAAHAIASLAQSGTISGKPVLTCWLGGRTARE
GRTLLQQAGLANYDTPSDVALAASYLAKWSKAQQALVRVPEGRDDEVHCNRDLGRSVLQR
VAAEGRRMLNEPEAKAVLAAYGIPVPQTIIATSPKEAEAIAGLLLAGAPKLVVKLISKSI
THKSDVGGVVLDILSPVAAREAAEAIVARLKAHDPIAVVDGFAVQPMIERKHAWELLLGV
TRDPIFGPVVLFGSGGVSVEVVADTAVALPPLDAVLAGDLIDETRVGKLLAGFRNEPAAD
RAAICKALTALSQLIVDFPCVLSMDINPLVASAEGVIALDGRIEINPRAVTRPGPNRDLA
IRPYPSEWQKQVTLAERRYHLRPIRPADAALYPDFLAKTSPADIRFRFLSSRKRFQDQML
VRLTQIDYEREMAFVALDSETGELVGISRLYADPDHEVAEYGLLIRTDLQGHGLGWALLA
YLREYASADGLKRIEGLILGDNAKMLKLCREFGFSISTHPGDATLRIATLALQSQASVS