Protein Info for SMa1087 in Sinorhizobium meliloti 1021

Annotation: cation transport P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 733 transmembrane" amino acids 79 to 99 (21 residues), see Phobius details amino acids 111 to 130 (20 residues), see Phobius details amino acids 142 to 166 (25 residues), see Phobius details amino acids 181 to 200 (20 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 363 to 385 (23 residues), see Phobius details amino acids 679 to 698 (20 residues), see Phobius details amino acids 704 to 726 (23 residues), see Phobius details PF19335: HMBD" amino acids 34 to 60 (27 residues), 49.9 bits, see alignment (E = 4.7e-17) TIGR01511: copper-translocating P-type ATPase" amino acids 125 to 729 (605 residues), 606.1 bits, see alignment E=1.5e-185 TIGR01525: heavy metal translocating P-type ATPase" amino acids 144 to 728 (585 residues), 629.6 bits, see alignment E=1.2e-192 TIGR01494: HAD ATPase, P-type, family IC" amino acids 189 to 697 (509 residues), 311.8 bits, see alignment E=1.3e-96 PF00122: E1-E2_ATPase" amino acids 218 to 399 (182 residues), 199.8 bits, see alignment E=5.5e-63 PF00702: Hydrolase" amino acids 417 to 633 (217 residues), 118 bits, see alignment E=1.4e-37

Best Hits

Swiss-Prot: 68% identical to SILP_SALTM: Silver exporting P-type ATPase (silP) from Salmonella typhimurium

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to sme:SMa1087)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZA2 at UniProt or InterPro

Protein Sequence (733 amino acids)

>SMa1087 cation transport P-type ATPase (Sinorhizobium meliloti 1021)
MGIDPNHHHSRTNVHAPPAQTEGSQVPTMEGVIYTCPMHPQVRQIGPGNCPICGMALEPA
VVTAETGPSAEFVDMRRRFWIGLVLTSPVLALEMGGHLTNLHMLLGAQTSNWLQLVFATP
VVLWAGAPFFERAWRSLVTRRLNMFTLIAMGTGVAWVYSVIATVAPGLFPATFRSADGAV
PIYFEAAAVITVLVLLGQVLELRAREQTGGAIRALLDLAPKTARRIRNDGTDEDLPLEAV
AVGDRLRVRPGEKVPVDGTLVEGRSSVDESMITGESMPVTKEVGAKLIGGTMNKTGGFVM
EAGKVGRDTMLSRIVQMVAEAQRSRAPIQRLADEVSGWFVPAVILIAIVAFVAWMWLGPE
PRFTHGLVAAVAVLIIACPCALGLATPMSIMVGVGQGARAGVLIKNAEALERFEKVNTLV
VDKTGTLTEGKSKVTSVVAVNGIAEDELLQVAATLERASEHPLAAAIVEAANVSRLGLGT
AENFDSPVGKGVTGTVKGHRLVIGSHQIMSEEKVDVAPLTEKAEALRGEGATVIFVAIDG
RVGGLFAISDPIKPTTPAAVAALMKDGVRVVMLTGDNRTTANAVARKLGITEVEAEILPE
HKSEIVRRLRNEGRVVAMAGDGVNDAPALAAADVGIAMGTGTDVAIESAGVTLLKGDLQG
IVRARQLSHATMRNIRQNLFFAFIYNAAGVPVAAGVLYPAFGLLLSPIIAAAAMALSSVS
VIGNSLRLRSTRI