Protein Info for SMa1038 in Sinorhizobium meliloti 1021

Annotation: copper-containing oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF07732: Cu-oxidase_3" amino acids 83 to 192 (110 residues), 121.2 bits, see alignment E=2.5e-39 PF07731: Cu-oxidase_2" amino acids 216 to 328 (113 residues), 80.7 bits, see alignment E=9.1e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa1038)

MetaCyc: 74% identical to MoxA manganese-oxidizing multicopper oxidase (Pedomicrobium sp. ACM 3067)
RXN-11646 [EC: 1.16.3.3]

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.16.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZC7 at UniProt or InterPro

Protein Sequence (449 amino acids)

>SMa1038 copper-containing oxidase (Sinorhizobium meliloti 1021)
MFNRRQLLGASAALVSTAAWAKTSNMGLPDAAVMETAETQGPLKPTSGPDYNPVVTLNGW
TLPHRMNNGVKEFHLVAEPVEREMAEDMTAYLWGYNGQSPGPTIEAVEGDRVRIFVTNKL
PEHTTIHWHGMILPSGMDGVGGLSQPHIPVGKTFVYEFDLVKSGTFMYHPHSDEMVQMAM
GMMGFFVIHPKDPKFMPVDRDFVFLLNAYDIDPGSYVPRIMEMTDFNMWCWNSRIFPDIS
PLVVSKNDRVRVRVGNLTMTNHPIHMHGYDFEVTCTDGGWVRPEARWPEVSIDIPVGAMR
AYEFDAKYAGDWAIHCHKSHHTMNAMGHDIPTFIGVDKSKVAEKIKKLRPEYMPMGTKGM
ADMGEMEMEIPENTIPMMTGWGPHGPIEMGGMFSVVKVREGISAGDYADPGWYENPPGTQ
AWEWTGELPDWTKAKDAKTQITPKHKNHG