Protein Info for SMa0939 in Sinorhizobium meliloti 1021

Annotation: sensor histidine kinase of two-component system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details transmembrane" amino acids 360 to 379 (20 residues), see Phobius details PF00512: HisKA" amino acids 410 to 474 (65 residues), 30.5 bits, see alignment E=3.2e-11 PF02518: HATPase_c" amino acids 520 to 630 (111 residues), 82.8 bits, see alignment E=2.5e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa0939)

Predicted SEED Role

"FIG01075569: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZH8 at UniProt or InterPro

Protein Sequence (633 amino acids)

>SMa0939 sensor histidine kinase of two-component system (Sinorhizobium meliloti 1021)
MIARSQARFGKIRVSPSCLNASAFICLLLVVIFAATGICSAQGAGPVPRVLILYPYDERI
PATNIVGEAARTRLVEATSGKVEVFSEFLDLSRFPKKGHVDRIARYLAEKYSDGRPDLVI
ALGEESTRFIVANRNAIAPDAKIVFGGFGNATAEELRLPNDVVGALTEFEIRKTVEMAIG
LQPDARQVVVIAGSAEFDKAWIAAAQEDLIGLPSDIETTYLTGLSIEEFVERVAALPPDT
IVIVLTVLSDRTGRNFVPRNSLEKIAKAASAPVYGPYSTYLDHGVVGGNAATFESTGTAV
AGLAIDALAGKAITDITVPQSYMADSRQLRRWGLSEADLPLGTAVLFKERSLWQEYWKEI
IAISAFVAAQSLVILSLVLERRRRAAAEFQARHRLLEVIHLNQSATAGALSASIAHELNQ
PLGAIRINAETAALMLERPNPDLKLIQQILADIRDDDQRAGDIIDRMRGLLRKRSEIDWQ
EFDLNDVVRSAIHILHPEAQRRDVTVSSVASAQGLPVRADRVHVQQVILNLAINAMDAML
QAPTAERNLMFQTAMVERNEKVEVSISDTGSGIPSDKLSNIFDAFYTTKPTGTGLGLSIA
RVIIEIYGGKLWADNRPQGGAVFRFVLPLARPG