Protein Info for SMa0765 in Sinorhizobium meliloti 1021

Annotation: cbb3-type cytochrome c oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 539 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 34 to 51 (18 residues), see Phobius details amino acids 72 to 99 (28 residues), see Phobius details amino acids 119 to 139 (21 residues), see Phobius details amino acids 151 to 173 (23 residues), see Phobius details amino acids 186 to 207 (22 residues), see Phobius details amino acids 219 to 242 (24 residues), see Phobius details amino acids 263 to 284 (22 residues), see Phobius details amino acids 295 to 313 (19 residues), see Phobius details amino acids 332 to 353 (22 residues), see Phobius details amino acids 365 to 385 (21 residues), see Phobius details amino acids 405 to 425 (21 residues), see Phobius details amino acids 444 to 463 (20 residues), see Phobius details amino acids 477 to 495 (19 residues), see Phobius details amino acids 501 to 520 (20 residues), see Phobius details TIGR00780: cytochrome c oxidase, cbb3-type, subunit I" amino acids 65 to 526 (462 residues), 791.4 bits, see alignment E=1.6e-242 PF00115: COX1" amino acids 71 to 501 (431 residues), 400 bits, see alignment E=6.8e-124

Best Hits

Swiss-Prot: 94% identical to FIXN_RHIME: Cytochrome c oxidase subunit 1 homolog, bacteroid (fixN) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00404, cb-type cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 100% identity to sme:SMa0765)

MetaCyc: 74% identical to cytochrome cbb3 oxidase subunit I (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZP0 at UniProt or InterPro

Protein Sequence (539 amino acids)

>SMa0765 cbb3-type cytochrome c oxidase subunit I (Sinorhizobium meliloti 1021)
MKHTVEMVVLAVGAFLALVGAGLAQDRLFGAHMWVLFFVLLGGTLVLMRRVDFRPAAAGR
RAGETEYFDEVVKYGVIATVFWGVVGFLVGVVVALQLAFPDLNVEPWFNFGRVRPLHTSA
VIFAFGGNALIATSFYVVQRTSRARLFGGDLGWFVFWGYQLFIVLAATGYLLGITQSREY
AEPEWYVDLWLTIVWVAYLAVFLGTVLMRKEPHIYVANWFYLAFIVTIAMLHIVNNLAVP
VSFMGSKSYSAFAGVQDALTQWWYGHNAVGFFLTAGFLAMMYYFIPKQVNRPVYSYRLSI
IHFWALIFMYIWAGPHHLHYTALPDWAQTLGMVFSIMLWMPSWGGMINGLMTLSGAWDKI
RTDPVVRMMVMAVAFYGMATFEGPMMSIKTVNSLSHYTDWTIGHVHSGALGWNGLITFGA
VYYLVPKLWNRERLYSLQMVNWHFWLATLGIVVYAATMWVAGIQQGLMWREYDDQGFLVY
SFAESVAAMFPYYVMRAAGGALFLAGALVMAFNVTMTILGRVRDEAAALDAAPLPAPAE