Protein Info for SMa0675 in Sinorhizobium meliloti 1021

Annotation: Ca2+/H+ antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 381 transmembrane" amino acids 27 to 46 (20 residues), see Phobius details amino acids 52 to 71 (20 residues), see Phobius details amino acids 83 to 104 (22 residues), see Phobius details amino acids 111 to 112 (2 residues), see Phobius details amino acids 114 to 137 (24 residues), see Phobius details amino acids 149 to 172 (24 residues), see Phobius details amino acids 184 to 204 (21 residues), see Phobius details amino acids 224 to 248 (25 residues), see Phobius details amino acids 259 to 283 (25 residues), see Phobius details amino acids 295 to 320 (26 residues), see Phobius details amino acids 327 to 347 (21 residues), see Phobius details amino acids 353 to 375 (23 residues), see Phobius details TIGR00378: calcium/proton exchanger" amino acids 32 to 373 (342 residues), 286.5 bits, see alignment E=1.5e-89 PF01699: Na_Ca_ex" amino acids 51 to 204 (154 residues), 54.3 bits, see alignment E=8e-19 amino acids 229 to 373 (145 residues), 69.2 bits, see alignment E=1.9e-23

Best Hits

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 100% identity to sme:SMa0675)

Predicted SEED Role

"cation (Ca) exchange protein, possible"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZU2 at UniProt or InterPro

Protein Sequence (381 amino acids)

>SMa0675 Ca2+/H+ antiporter (Sinorhizobium meliloti 1021)
MRTFEVKGSTKQSRSAIETVLRELRRSPLLALIFFVPVVILLERMAPKAHTLLFFVAIAA
IVPLAALLSRATESVAAKTGDAVGGLLNATLGNLTELIITLAALQAGQYLLVKASIAGAI
VTNSLFMFGGAFLIGGLKHHLQEFNRVNARFQAILLFLATIAILVPSLTSGLDRTPAAEF
SQQLSLGLAILLIVVYGLGMVFSLKTHKELFASVGQAEAGEEPWPLSIGIVVLIVVTLLV
AMVSEIFVGSVQAAAQHLGLTPAFVGFIVIALVGGAAEMTTAFSAARANRLDLSVGIALG
SAAQIALFVAPVLVLVSYFIGPQPMSLEFWPGAVAMMLVATMAATLLSNGGHAAWYAGVM
ALAVYAIFALTLFLLPPGVTQ