Protein Info for SMa0281 in Sinorhizobium meliloti 1021

Annotation: MerR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 134 PF13411: MerR_1" amino acids 11 to 76 (66 residues), 62.6 bits, see alignment E=4.4e-21 PF00376: MerR" amino acids 11 to 47 (37 residues), 37.3 bits, see alignment E=3e-13 PF09278: MerR-DNA-bind" amino acids 52 to 114 (63 residues), 62.9 bits, see alignment E=5.4e-21

Best Hits

Swiss-Prot: 48% identical to MERR_SERMA: Mercuric resistance operon regulatory protein (merR) from Serratia marcescens

KEGG orthology group: K08365, MerR family transcriptional regulator, mercuric resistance operon regulatory protein (inferred from 100% identity to sme:SMa0281)

Predicted SEED Role

"Mercuric resistance operon regulatory protein" in subsystem Mercury resistance operon

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q930P4 at UniProt or InterPro

Protein Sequence (134 amino acids)

>SMa0281 MerR family transcriptional regulator (Sinorhizobium meliloti 1021)
MVQSQDLQELTIGKLAAAGGVGVETIRFYQRKGLLATPKRLEGVRRYGGEDVRRLRFIKQ
AQAAGFTLEEIGQLLALDAGHNRSAARELAKKKLEQLDARIGELNRAREALRKLVSECAE
DKTGPCPILASFGV