Protein Info for SMa0113 in Sinorhizobium meliloti 1021

Annotation: Sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 853 PF08448: PAS_4" amino acids 37 to 154 (118 residues), 34.5 bits, see alignment E=1.1e-11 amino acids 170 to 276 (107 residues), 29.1 bits, see alignment E=5e-10 amino acids 299 to 404 (106 residues), 36.7 bits, see alignment E=2.2e-12 amino acids 420 to 533 (114 residues), 27.9 bits, see alignment E=1.2e-09 amino acids 549 to 656 (108 residues), 55.6 bits, see alignment E=2.9e-18 PF13426: PAS_9" amino acids 43 to 151 (109 residues), 35.3 bits, see alignment E=5.8e-12 amino acids 179 to 273 (95 residues), 30.2 bits, see alignment E=2.3e-10 amino acids 299 to 401 (103 residues), 39.9 bits, see alignment E=2.2e-13 amino acids 425 to 531 (107 residues), 24.2 bits, see alignment E=1.7e-08 amino acids 551 to 653 (103 residues), 69.3 bits, see alignment E=1.6e-22 PF00989: PAS" amino acids 165 to 259 (95 residues), 25.1 bits, see alignment E=7.5e-09 amino acids 288 to 391 (104 residues), 52.8 bits, see alignment E=1.8e-17 amino acids 414 to 451 (38 residues), 23.8 bits, see alignment (E = 1.9e-08) amino acids 541 to 651 (111 residues), 68.1 bits, see alignment E=3.4e-22 PF13188: PAS_8" amino acids 166 to 218 (53 residues), 17.2 bits, see alignment 2e-06 amino acids 287 to 343 (57 residues), 25.5 bits, see alignment 4.7e-09 amino acids 416 to 463 (48 residues), 27 bits, see alignment 1.6e-09 amino acids 540 to 593 (54 residues), 23.7 bits, see alignment 1.8e-08 TIGR00229: PAS domain S-box protein" amino acids 166 to 281 (116 residues), 46.4 bits, see alignment E=2e-16 amino acids 283 to 406 (124 residues), 75.8 bits, see alignment E=1.6e-25 amino acids 410 to 537 (128 residues), 41.5 bits, see alignment E=6.8e-15 amino acids 539 to 659 (121 residues), 108.1 bits, see alignment E=1.6e-35 PF08447: PAS_3" amino acids 310 to 389 (80 residues), 38.3 bits, see alignment E=6.7e-13 amino acids 564 to 646 (83 residues), 32.1 bits, see alignment E=5.9e-11 PF07568: HisKA_2" amino acids 667 to 729 (63 residues), 30 bits, see alignment 2.3e-10 PF07536: HWE_HK" amino acids 667 to 747 (81 residues), 96.2 bits, see alignment E=7.9e-31

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa0113)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q930Y7 at UniProt or InterPro

Protein Sequence (853 amino acids)

>SMa0113 Sensor histidine kinase (Sinorhizobium meliloti 1021)
MKSRESPVYMSNVEEFPLTGRVLTEYEALITSAPTALDAIPGAVYVCDHEGWLVGYNAEA
AELWGRQPSLSAPRERFCGSQRLFLSDGSPMDHQECPMAEAIKTGVSTRNAEVIIERPDG
SRIFALVNIRPLRDHRGVIQGAINCFQDISQQKRIEAEVNCKSKDLEDFFENSAIGLHIV
SAAGIILRANKAELELLGYPADEYVGRHIAEFHADAPVIGDILDRLSCGEKLDRYPARLR
ARDGSIKHVLITSNSRFEDGKFVNTRCFTTDITSLHETENAWRETEERLAATYQAATIGI
AESDADGRLLRVNDAFCTMLGRSREQLLNMTFLDYTHEDDRDEEARCYARQVSGETDTYA
IRKRAVKADGTVIYLDVYSSTVRDRTGRFRYGVRVLLDVTEAKRMDDRRRESEQHMRDLL
EALPAAVYTTDAEGRITFFNKAAVEMAGRTPQIGDKWCVTWRLYRPDGTYLPHDQCPMAV
TLKEDRPVRGEQAVAERPDGTRVPFIPYPTPLHDVAGKLVGAVNMLVDISDREKAAEYAE
RLASIVRFSDDAIVSKDTQGIIQTWNKGAERLFGYSAEEVIGKPINILIPPDRQGEEPGI
LERIRRDEHIDHYETVRIRKDGSLIDVSLTVSPLKDARGRVVGASKIARDITERRRSEEH
RKLLVNELNHRVKNTLATVQSLAAQTFRGVNASEDFGRFQSRLVALARAHDVLTRESWQG
ADLGEVLHATINPICVEPQQRVQASGPPLRLRPKMALALSMAFHELCTNAAKYGALTNDG
GLIKVNWHVSNIESVSHLHLQWEEIGGPSVMVPARTGFGTRLLERALARELGGKVDLVFA
PSGVRFHIEAPLT