Protein Info for SM_b21383 in Sinorhizobium meliloti 1021

Annotation: SDR family dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 57 to 243 (187 residues), 164.1 bits, E=5.7e-52
• PF01370: Epimerase
  • amino acids 59 to 221 (163 residues), 24.9 bits, E=2.5e-09
• PF08659: KR
  • amino acids 59 to 215 (157 residues), 52.5 bits, E=1.2e-17
• PF13561: adh_short_C2
  • amino acids 65 to 295 (231 residues), 183 bits, E=1.5e-57

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b21383)

MetaCyc: 36% identical to lyngbyatoxin A monooxygenase (Moorena producens)
1.14.13.-; 1.14.13.-

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (49/53 steps found)
• palmitate biosynthesis III (28/29 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• anteiso-branched-chain fatty acid biosynthesis (30/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (23/25 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (18/20 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (15/16 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (12/12 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• (5Z)-dodecenoate biosynthesis I (6/6 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
• fatty acid elongation -- saturated (5/5 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• (5Z)-dodecenoate biosynthesis II (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• 8-amino-7-oxononanoate biosynthesis I (8/11 steps found)
• stearate biosynthesis IV (4/6 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (3/5 steps found)
• lyngbyatoxin biosynthesis (2/5 steps found)
• biotin biosynthesis I (9/15 steps found)
• petroselinate biosynthesis (2/6 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (21/205 steps found)
• superpathway of mycolate biosynthesis (22/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100

Sequence Analysis Tools

See Q92UX4 at UniProt or InterPro

Protein Sequence (296 amino acids)

>SM_b21383 SDR family dehydrogenase (Sinorhizobium meliloti 1021)
MKVTDNQNVSGTNAVSRRKLLAGAGVLATSAAMAGLAQAQSAATPDGTVPGTAGRPRVAL
VTGSSRGIGAATARQLGRDGYRVVVNCVVNRDLAAQVAREIEASGSPAIWRQADVRDPAA
VRALFDAGEEAFGGIDVVVANAGVMHLAPFADMSDEDVNHMFDVNILGSFHTLREAARRV
RDGGRIFPLSSTITRFRTETYGPYAASKMAQELYATVLAKELAGRNISVNAIAPGVVNTT
LFTDGKTEAELAGFVKRTPHGRLGEPNDIANVISLLCSGGASWVNGQVVYANGGIA