Protein Info for SM_b21377 in Sinorhizobium meliloti 1021

Annotation: sugar uptake ABC transporter substrate-binding protein precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF00532: Peripla_BP_1" amino acids 28 to 284 (257 residues), 66.4 bits, see alignment E=4.5e-22 PF13407: Peripla_BP_4" amino acids 29 to 280 (252 residues), 187.1 bits, see alignment E=7e-59 PF13377: Peripla_BP_3" amino acids 163 to 291 (129 residues), 30.4 bits, see alignment E=5.9e-11

Best Hits

KEGG orthology group: K10439, ribose transport system substrate-binding protein (inferred from 100% identity to sme:SM_b21377)

Predicted SEED Role

"Ribose ABC transporter, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1)" in subsystem Bacterial Chemotaxis (TC 3.A.1.2.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q926G6 at UniProt or InterPro

Protein Sequence (296 amino acids)

>SM_b21377 sugar uptake ABC transporter substrate-binding protein precursor (Sinorhizobium meliloti 1021)
MNMPRILKTLVAGTALTLLASGAFADGIGASLLTQQHPFYIELAEAMKAEAKEKNVALEV
AIANQDLNKQLADVEDFIVKGVDVIVISPVDSQGVRAAIAKAEKAGIKVITVDVPANGAT
VTSHIGTDNFTGGVKAGELMAEVLGNKGKVAIIDYPTVQSVVNRVNGFKEAIAKHPEMEI
VATQTGITRAEALAAAQNMLQANPDITGIFGFGDDAALAAAVAVKAAGLESQVKVIGFDG
MKEARDAVDGNPVMVGVIQQFPDQMGKQAIDTAVKVVAGETVPAEQPIVPGVYTGK